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Abstract：
BACKGROUND: Escherichia coli commonly causes catheter-related bloodstream infection (C-RBSI) in specific populations. The differential time to positivity (DTTP) technique is the recommended conservative procedure for diagnosing C-RBSIs.
METHODS: We conducted a retrospective study of episodes in which E. coli was isolated from catheter lumens obtained using the DTTP technique. Microbiological and clinical data were obtained based on the DTTP technique as either catheter colonization, C-RBSI, or non-C-RBSI.
RESULTS: A total of 89 catheter blood cultures were included, classified as follows: catheter colonization, 33.7%; C-RBSI, 9.0%; and non-C-RBSI, 57.3%. Only 15.7% of the catheters were withdrawn, with no positive catheter-tip cultures. We found no statistically significant differences in catheter type, antibiotic treatment, or clinical outcome among the groups, except for the frequency of catheter lock therapy or in the frequency of successful treatment. Mortality was associated with C-RBSI in only one patient.
CONCLUSIONS: E. coli bacteremia diagnosed by the DTTP technique was classified as non-catheter-related in most patients. As the majority of the catheters were retained, E. coli bacteremia could not be microbiologically confirmed as catheter-related by the catheter-tip culture. Future studies are needed to assess the profitability of the DTTP technique for diagnosing E. coli C-RBSIs.
METHODS: We conducted a retrospective study of episodes in which E. coli was isolated from catheter lumens obtained using the DTTP technique. Microbiological and clinical data were obtained based on the DTTP technique as either catheter colonization, C-RBSI, or non-C-RBSI.
RESULTS: A total of 89 catheter blood cultures were included, classified as follows: catheter colonization, 33.7%; C-RBSI, 9.0%; and non-C-RBSI, 57.3%. Only 15.7% of the catheters were withdrawn, with no positive catheter-tip cultures. We found no statistically significant differences in catheter type, antibiotic treatment, or clinical outcome among the groups, except for the frequency of catheter lock therapy or in the frequency of successful treatment. Mortality was associated with C-RBSI in only one patient.
CONCLUSIONS: E. coli bacteremia diagnosed by the DTTP technique was classified as non-catheter-related in most patients. As the majority of the catheters were retained, E. coli bacteremia could not be microbiologically confirmed as catheter-related by the catheter-tip culture. Future studies are needed to assess the profitability of the DTTP technique for diagnosing E. coli C-RBSIs.
摘要：
背景：大肠杆菌通常在特定人群中引起导管相关性血流感染（C-RBSI）。阳性差分时间（DTTP）技术是诊断C-RBSI的推荐保守程序。
方法：我们对使用DTTP技术从导管腔中分离出大肠杆菌的事件进行了回顾性研究。根据DTTP技术获得的微生物和临床数据作为导管定植，C-RBSI,或非C-RBSI。
结果：共包括89个导管血培养，分类如下：导管定植，33.7%；C-RBSI，9.0%；和非C-RBSI，57.3%。只有15.7%的导管被撤回,导管尖端无阳性培养。我们发现导管类型没有统计学上的显著差异，抗生素治疗,或组中的临床结果，导管锁定治疗的频率或成功治疗的频率除外。只有一名患者的死亡率与C-RBSI相关。
结论：E.在大多数患者中,通过DTTP技术诊断的大肠杆菌菌血症被归类为非导管相关性.由于保留了大部分导管，通过导管尖端培养，无法在微生物学上确认大肠杆菌菌血症与导管相关。需要未来的研究来评估DTTP技术诊断大肠杆菌C-RBSI的盈利能力。
方法：我们对使用DTTP技术从导管腔中分离出大肠杆菌的事件进行了回顾性研究。根据DTTP技术获得的微生物和临床数据作为导管定植，C-RBSI,或非C-RBSI。
结果：共包括89个导管血培养，分类如下：导管定植，33.7%；C-RBSI，9.0%；和非C-RBSI，57.3%。只有15.7%的导管被撤回,导管尖端无阳性培养。我们发现导管类型没有统计学上的显著差异，抗生素治疗,或组中的临床结果，导管锁定治疗的频率或成功治疗的频率除外。只有一名患者的死亡率与C-RBSI相关。
结论：E.在大多数患者中,通过DTTP技术诊断的大肠杆菌菌血症被归类为非导管相关性.由于保留了大部分导管，通过导管尖端培养，无法在微生物学上确认大肠杆菌菌血症与导管相关。需要未来的研究来评估DTTP技术诊断大肠杆菌C-RBSI的盈利能力。
