PDF(Pubmed)
Abstract：
This narrative review delves into the evolving landscape of fertility preservation techniques, with a particular focus on their use in patients undergoing oncology treatment that carries a risk of ovarian insufficiency. Advances in established methods such as cryopreservation of oocytes and embryos are highlighted, and the increasing use of gonadotropin-releasing hormone (GnRH) agonists is discussed. The review also addresses the complexities and controversies associated with these approaches, such as the \'flare-up\' effect associated with GnRH agonists and the potential of GnRH antagonists to reduce the risk of ovarian hyperstimulation syndrome. Despite advances in fertility preservation, the report highlights the challenges we face, including the need for personalized treatment protocols and the management of associated risks. It calls for continued research and collaboration between healthcare professionals to refine these techniques and ultimately improve reproductive outcomes for patients facing the prospect of fertility-impairing treatment.
摘要：
这篇叙述性评论深入探讨了生育力保存技术的不断发展的景观，特别关注它们在接受肿瘤治疗的患者中的使用，这些患者有卵巢功能不全的风险。重点介绍了卵母细胞和胚胎冷冻保存等既定方法的进展，并讨论了促性腺激素释放激素（GnRH）激动剂的使用增加。审查还解决了与这些方法相关的复杂性和争议，例如与GnRH激动剂相关的“突然发作”效应和GnRH拮抗剂降低卵巢过度刺激综合征风险的潜力。尽管在生育力保护方面取得了进展，报告强调了我们面临的挑战，包括个性化治疗方案的需要和相关风险的管理。它呼吁医疗保健专业人员之间继续进行研究和合作，以完善这些技术，并最终改善面临生育障碍治疗前景的患者的生殖结果。
