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Abstract：
Clavatols exhibit a wide range of biological activities due to their diverse structures. A genome mining strategy identified an A5cla cluster from Penicillium sp. MYA5, derived from the Arctic plant Dryas octopetala, is responsible for clavatol biosynthesis. Seven clavatols, including one new clavatol derivate named penicophenone F (1) and six known clavatols (2-7), were isolated from Penicillium sp. MYA5 using a transcriptome mining strategy. These structures were elucidated by comprehensive spectroscopic analysis. Antibacterial, aldose reductase inhibition, and siderophore-producing ability assays were conducted on compounds 1-7. Compounds 1 and 2 demonstrated inhibitory effects on the ALR2 enzyme with inhibition rates of 75.3% and 71.6% at a concentration of 10 μM, respectively. Compound 6 exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 4.0 μg/mL and 4.0 μg/mL, respectively. Additionally, compounds 1, 5, and 6 also showed potential iron-binding ability.
摘要：
Clavatols由于其不同的结构而表现出广泛的生物活性。基因组挖掘策略从青霉菌中确定了一个A5cla簇。MYA5，来自北极植物Dryasoctopetala，负责克拉沃托的生物合成。七个克拉沃尔，包括一种名为penicophenoneF（1）的新克拉沃醇衍生物和六种已知的克拉沃醇（2-7），从青霉菌中分离。使用转录组挖掘策略的MYA5。通过全面的光谱分析阐明了这些结构。抗菌,醛糖还原酶抑制，对化合物1-7进行了铁载体产生能力测定。化合物1和2在10μM浓度下对ALR2酶表现出抑制作用，抑制率分别为75.3％和71.6％。分别。化合物6对金黄色葡萄球菌和大肠杆菌具有抗菌活性,MIC值分别为4.0μg/mL和4.0μg/mL,分别。此外,化合物1、5和6也显示出潜在的铁结合能力。
