PDF(Pubmed)
Abstract：
Obesity is a systemic and chronic inflammation, which seriously endangers people\'s health. People tend to diet to control weight, and the short-term effect of dieting in losing weight is significant, but the prognosis is limited. With weight loss and recovery occurring frequently, people focus on weight cycling. The effect of weight cycling on a certain tissue of the body also has different conclusions. Therefore, this article systematically reviews the effects of body weight cycling on the body and finds that multiple weight cycling (1) increased fat deposition in central areas, lean mass decreased in weight loss period, and fat mass increased in weight recovery period, which harms body composition and skeletal muscle mass; (2) enhanced the inflammatory response of adipose tissue, macrophages infiltrated into adipose tissue, and increased the production of pro-inflammatory mediators in adipocytes; (3) blood glucose concentration mutation and hyperinsulinemia caused the increase or decrease in pancreatic β-cell population, which makes β-cell fatigue and leads to β-cell failure; (4) resulted in additional burden on the cardiovascular system because of cardiovascular rick escalation. Physical activity combined with calorie restriction can effectively reduce metabolic disease and chronic inflammation, alleviating the adverse effects of weight cycling on the body.
摘要：
肥胖是一种全身性慢性炎症,严重危害人们的健康。人们倾向于节食来控制体重，节食减肥的短期效果是显著的，但预后有限。随着体重减轻和恢复的频繁发生，人们专注于体重骑自行车。体重循环对身体某些组织的影响也有不同的结论。因此,本文系统地回顾了体重循环对身体的影响，发现多重体重循环(1)增加了中部地区的脂肪沉积，瘦体重在减肥期减少，在体重恢复期脂肪量增加，伤害身体成分和骨骼肌质量；（2）增强脂肪组织的炎症反应，巨噬细胞渗入脂肪组织，并增加了脂肪细胞中促炎介质的产生；（3）血糖浓度突变和高胰岛素血症引起胰腺β细胞群的增加或减少，导致β细胞疲劳并导致β细胞衰竭；（4）由于心血管疾病加重而对心血管系统造成额外负担。体力活动结合热量限制可以有效减少代谢性疾病和慢性炎症，减轻体重循环对身体的不利影响。
