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Abstract：
The skin mycobiota plays a significant role in infection risk, pathogen transmission, and personalized medicine approaches in intensive care settings. This prospective multicenter study aimed to enhance our understanding of intensive care units\' (ICUs\') Candida colonization dynamics, identify modifiable risk factors, and assess their impact on survival risk. Specimens were taken from 675, 203, and 110 patients at the admission (D1), 5th (D5), and 8th (D8) days of ICU stay, respectively. The patient\'s demographic and clinical data were collected. Candida isolates were identified by conventional culture-based microbiology combined with molecular approaches. Overall, colonization was 184/675 (27.3%), 87/203 (42.8%), and 58/110 (52.7%) on D1, D5, and D8, respectively. Candida colonization dynamics were significantly associated with ICU type (odds ratio (OR) = 2.03, 95% CI 1.22-3.39, p = 0.007), respiratory infection (OR = 1.74, 95% CI 1.17-2.58, p = 0.006), hemodialysis (OR = 2.19, 95% CI 1.17-4.10, p = 0.014), COVID-19 (OR = 0.37, 95% CI 0.14-0.99, p = 0.048), and with a poor 3-month outcome (p = 0.008). Skin Candida spp. colonization can be an early warning tool to generate valuable insights into the epidemiology, risk factors, and survival rates of critically ill patients, and should be considered for epidemiological surveillance.
摘要：
皮肤分枝杆菌在感染风险中起着重要作用，病原体传播,和重症监护环境中的个性化医疗方法。这项前瞻性多中心研究旨在增强我们对重症监护病房（ICU）念珠菌定植动力学的理解，识别可修改的风险因素，并评估其对生存风险的影响。标本取自675、203和110名患者在入院时（D1），5th(D5),住ICU的第8天(D8天),分别。收集患者的人口统计学和临床数据。通过基于常规培养的微生物学结合分子方法鉴定念珠菌分离物。总的来说,定植为184/675（27.3%），87/203（42.8%），D1、D5和D8分别为58/110(52.7%)。念珠菌定植动力学与ICU类型显著相关(比值比(OR)=2.03,95%CI1.22-3.39,p=0.007),呼吸道感染（OR=1.74，95%CI1.17-2.58，p=0.006），血液透析（OR=2.19，95%CI1.17-4.10，p=0.014），COVID-19（OR=0.37，95%CI0.14-0.99，p=0.048），3个月的结果较差（p=0.008）。皮肤念珠菌属。定殖可以成为一种预警工具，可以对流行病学产生有价值的见解，危险因素，和危重病人的生存率，并应考虑进行流行病学监测。
