PDF(Pubmed)
Abstract：
The brain is the most complex organ in the human body and, as such, its study entails great challenges (methodological, theoretical, etc.). Nonetheless, there is a remarkable amount of studies about the consequences of pathological conditions on its development and functioning. This bibliographic review aims to cover mostly findings related to changes in the physical distribution of neurons and their connections-the connectome-both structural and functional, as well as their modelling approaches. It does not intend to offer an extensive description of all conditions affecting the brain; rather, it presents the most common ones. Thus, here, we highlight the need for accurate brain modelling that can subsequently be used to understand brain function and be applied to diagnose, track, and simulate treatments for the most prevalent pathologies affecting the brain.
摘要：
大脑是人体最复杂的器官,因此，它的研究带来了巨大的挑战(方法论，理论,等。).尽管如此，关于病理状况对其发展和功能的影响的研究非常多。这篇书目综述旨在涵盖与神经元及其连接的物理分布变化有关的主要发现-连接组-结构和功能，以及他们的建模方法。它并不打算对影响大脑的所有情况进行广泛的描述；相反，它提出了最常见的。因此，在这里，我们强调需要精确的大脑建模，然后可以用来了解大脑功能，并应用于诊断，轨道,并模拟影响大脑的最普遍病理的治疗方法。
