PDF(Pubmed)
Abstract：
Elevated immunoglobulin E (IgE) levels are commonly associated with allergies. However, high IgE levels are also found in several other infectious and non-infectious disorders. Elevated IgE levels typically suggest allergies, eczema, or recurrent skin infections. Hyperimmunoglobulin E (hyper-IgE) levels typically reflect a monogenic atopic condition or inborn immune defects with an atopic phenotype. The aim of our research is to investigate and observe the clinical characteristics of children with increased IgE levels who have previously manifested infectious diseases. Furthermore, the retrospective study considers other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on IgE serum levels. To answer this question, we conducted a one-year hospital-based retrospective study that included 200 hospitalized children who had at least two viral or bacterial infections in the six months preceding hospitalization. Measurements of IgE and allergen panels (respiratory and digestive) using blood samples revealed that individuals who tested positive for the body\'s synthesis of hyper-IgE were not observably allergic to any potential allergens despite having higher total serum IgE. According to the results, there was a strong correlation between elevated IgE serum levels and a history of infectious diseases among the patients.
摘要：
免疫球蛋白E（IgE）水平升高通常与过敏有关。然而,在其他几种感染性和非感染性疾病中也发现了高IgE水平。IgE水平升高通常提示过敏，湿疹,或复发性皮肤感染。高免疫球蛋白E(hyper-IgE)水平通常反映单基因特应性病症或具有特应性表型的先天性免疫缺陷。我们研究的目的是调查和观察先前表现出感染性疾病的IgE水平升高的儿童的临床特征。此外，回顾性研究考虑了其他因素，如人口统计特征(性别，区域/环境,和年龄），以及它们对IgE血清水平的影响。为了回答这个问题,我们进行了一项为期1年的以医院为基础的回顾性研究,纳入了200名住院儿童,这些儿童在住院前6个月内发生了至少2次病毒或细菌感染.使用血液样本对IgE和过敏原组（呼吸和消化）的测量显示，尽管血清总IgE较高，但对身体高IgE合成呈阳性的个体对任何潜在过敏原均未观察到过敏。根据结果,血清IgE水平升高与患者的感染性疾病史之间有很强的相关性.
