PDF(Pubmed)
Abstract：
Over one million Syrian refugees have been residing in substandard living conditions in Lebanon for the past decade. Non-invasive biomonitoring of fractional exhaled nitric oxide (FeNO) as a pulmonary inflammation biomarker was conducted following and preceding indoor environmental assessments (which revealed elevated mould counts in informal tented settlements and non-residential shelters) to further evaluate effects of environmental exposure to indoor contaminants. Results of biomonitoring (n = 57) provided some insight regarding existing respiratory conditions and the possible implementation of minimally invasive methods to establish susceptibility profiles in Syrian refugees amid limited access to healthcare. The clinical interpretation of FeNO results suggested possible persistent exposure to allergens in addition to significant type 2 inflammation in some subjects. These findings warrant the need to expand this study, investigate other biomarkers, and attempt to correlate findings with environmental conditions to evaluate if a dose-response relationship exists.
摘要：
在过去的十年中，黎巴嫩有100多万叙利亚难民居住在不合格的生活条件下。在室内环境评估之后和之前进行了部分呼出气一氧化氮（FeNO）作为肺部炎症生物标志物的非侵入性生物监测（揭示了非正式帐篷住区和非住宅庇护所中霉菌计数升高），以进一步评估环境暴露于室内污染物的影响。生物监测结果（n=57）提供了一些有关现有呼吸状况的见解，以及在医疗服务有限的情况下，可能实施微创方法以建立叙利亚难民的易感性特征。FeNO结果的临床解释表明，除了某些受试者的显着2型炎症外，还可能持续暴露于过敏原。这些发现保证了扩大这项研究的必要性，调查其他生物标志物，并尝试将发现与环境条件相关联，以评估是否存在剂量反应关系。
