PDF(Pubmed)
Abstract：
Respiratory diseases, including respiratory syncytial virus (RSV) infections, are common reasons for seeking healthcare among refugees and asylum seekers. A systematic review with meta-analysis was designed to appraise all the available evidence on RSV infections among individuals in refugee camps. Three medical databases (PubMed, Embase, and Scopus) as well as the preprint repository medRxiv.org were searched for eligible observational studies, and the collected cases were pooled in a random-effects meta-analysis model. Heterogeneity was assessed using the I2 statistics. Funnel plots and a regression analysis were calculated for analyzing reporting bias. Eventually, six studies were retrieved from three areas (Bangladesh, Thailand, and Kenya), with pooled estimates of 129.704 cases per 1000 samples (95% CI 66.393 to 237.986) for RSV compared to 110.287 per 1000 people for influenza A (95% CI 73.186 to 162.889), 136.398 cases per 1000 people (95% CI 84.510 to 212.741) for human adenovirus (HAdV), 69.553 per 1000 people (95% CI 49.802 to 96.343) for parainfluenzavirus (PIFV), and 60.338 per 1000 people (95% CI 31.933 to 111.109) for human metapneumovirus (hMPV). Using influenza A as a reference group, the risk for a positive specimen was greater for RSV (relative risk [RR] 1.514, 95% CI 1.396 to 1.641) and HAdV (RR 1.984, 95% CI 1.834 to 2.146) and lower for influenza B (RR 0.276, 95% CI: 0.239 to 0.319), PIFV (RR: 0.889, 95% CI 0.806 to 0.981), and hMPV (RR 0.594, 95% CI 0.534 to 0.662). In summary, high rates of RSV infections were documented among individuals sheltered in refugee camps, stressing the importance of specifically designed preventive strategies.
摘要：
呼吸系统疾病,包括呼吸道合胞病毒（RSV）感染，是难民和寻求庇护者寻求医疗保健的常见原因。设计了一项带有荟萃分析的系统评价，以评估难民营中个人RSV感染的所有可用证据。三个医疗数据库(PubMed，Embase,和Scopus）以及预印本存储库medRxiv.org进行了搜索，以获取合格的观察性研究，并将收集的病例合并到随机效应荟萃分析模型中.使用I2统计量评估异质性。计算漏斗图和回归分析以分析报告偏差。最终,从三个地区检索了六项研究(孟加拉国，泰国,和肯尼亚)，RSV的汇总估计为每1000个样本129.704例（95％CI66.393至237.986），而甲型流感为每1000人110.287例（95％CI73.186至162.889），136.398例/1000人腺病毒（HAdV）（95%CI84.510至212.741），副流感病毒（PIFV）为69.553/1000人（95％CI49.802至96.343），人类偏肺病毒（hMPV）为60.338/1000人（95％CI31.933至111.109）。以甲型流感为参照组,阳性样本的风险在RSV（相对风险[RR]1.514，95%CI1.396至1.641）和HAdV（RR1.984，95%CI1.834至2.146）中较大，在乙型流感中较低（RR0.276，95%CI：0.239至0.319），PIFV（RR：0.889，95%CI0.806至0.981），和hMPV（RR0.594，95%CI0.534至0.662）。总之,在难民营中庇护的个人中，RSV感染率很高，强调专门设计的预防策略的重要性。
