PDF(Pubmed)
Abstract：
Ischemia-reperfusion injury (IRI) during liver transplantation has been implicated in the recurrence of hepatocellular carcinoma (HCC). This systematic review aimed to evaluate interventions to reduce IRI during liver transplantation for HCC and their impact on oncologic outcomes. A comprehensive literature search retrieved four retrospective studies involving 938 HCC patients, utilising interventions such as post-operative prostaglandin administration, hypothermic machine perfusion, and normothermic machine perfusion. Overall, treated patients exhibited reduced post-operative hepatocellular injury and inflammation and significantly enhanced recurrence-free survival. Despite these promising results, the impact of these interventions on overall survival remains unclear. This underscores the imperative for further prospective research to comprehensively understand the efficacy of these interventions in HCC patients undergoing transplantation. The findings highlight the potential benefits of these strategies while emphasising the need for continued investigation into their overall impact.
摘要：
肝移植过程中的缺血再灌注损伤（IRI）与肝细胞癌（HCC）的复发有关。本系统评价旨在评估肝癌肝移植期间降低IRI的干预措施及其对肿瘤学结果的影响。一项全面的文献检索检索到四项回顾性研究，涉及938例HCC患者，利用干预措施，如术后前列腺素给药，低温机器灌注，和常温机灌注。总的来说,接受治疗的患者术后肝细胞损伤和炎症减少,无复发生存率显著提高.尽管这些有希望的结果，这些干预措施对总生存期的影响尚不清楚.这强调了进一步前瞻性研究的必要性，以全面了解这些干预措施在接受移植的HCC患者中的疗效。调查结果强调了这些策略的潜在好处，同时强调需要继续调查其整体影响。
