PDF(Pubmed)
Abstract：
Recent emerging studies have demonstrated numerous critical roles of exosomes in cell-to-cell signaling. We investigated exosomes in the aqueous humor of glaucoma patients and controls and compared their characteristics with other biomarkers such as cytokines. Glaucoma patients exhibited higher exosome particle counts and smaller sizes compared to controls. Higher exosome density was correlated with more severe visual field loss. Conversely, concentrations of aqueous humor cytokines, particularly PD-L1, were primarily associated with intraocular pressure, and none of the cytokines showed a significant association with visual field damage. This may reflect the characteristics of exosomes, which are advantageous for crossing various biological barriers. Exosomes may contain more information about glaucoma functional damage occurring in the retina or optic nerve head. This highlights the potential importance of exosomes as signaling mediators distinct from other existing molecules.
摘要：
最近的新兴研究已经证明了外来体在细胞间信号传导中的许多关键作用。我们研究了青光眼患者和对照组房水中的外泌体，并将其特征与其他生物标志物如细胞因子进行了比较。与对照相比,青光眼患者表现出较高的外泌体颗粒计数和较小的尺寸。较高的外来体密度与更严重的视野丧失相关。相反，房水细胞因子的浓度，尤其是PD-L1，主要与眼压有关，没有一个细胞因子与视野损伤有显著关联。这可能反映了外泌体的特征，有利于跨越各种生物屏障。外泌体可能包含有关视网膜或视神经乳头中发生的青光眼功能损害的更多信息。这突出了外来体作为不同于其他现有分子的信号传导介质的潜在重要性。
