PDF(Pubmed)
Abstract：
The world of cancer treatment is evolving rapidly and has improved the prospects of many cancer patients. Yet, there are still many cancers where treatment prospects have not (or hardly) improved. Glioblastoma is the most common malignant primary brain tumor, and even though it is sensitive to many chemotherapeutics when tested under laboratory conditions, its clinical prospects are still very poor. The blood-brain barrier (BBB) is considered at least partly responsible for the high failure rate of many promising treatment strategies. We describe the workings of the BBB during healthy conditions and within the glioblastoma environment. How the BBB acts as a barrier for therapeutic options is described as well as various approaches developed and tested for passing or opening the BBB, with the ultimate aim to allow access to brain tumors and improve patient perspectives.
摘要：
癌症治疗的世界正在迅速发展，并改善了许多癌症患者的前景。然而，仍然有许多癌症的治疗前景没有（或几乎没有）改善。胶质母细胞瘤是最常见的恶性原发性脑肿瘤，尽管它在实验室条件下测试时对许多化疗药物敏感，其临床前景仍然很差。血脑屏障（BBB）被认为是许多有希望的治疗策略的高失败率的至少部分原因。我们描述了在健康状况和胶质母细胞瘤环境中BBB的运作。描述了BBB如何作为治疗选择的障碍，以及开发和测试用于通过或打开BBB的各种方法。最终目的是允许进入脑肿瘤并改善患者的观点。
