Abstract：
OBJECTIVE: To describe the natural history of inhibin B throughout life according to sex, age, and pubertal development.
METHODS: Based on serum samples from 2707 healthy controls aged 0 to 80 years, sex- and age-specific reference ranges of inhibin B concentrations were constructed. Concentrations were evaluated according to pubertal development and use of oral contraceptives (OCs). Also, measurements from 42 patients with Klinefelter syndrome were included.
RESULTS: In both sexes, inhibin B concentrations were high during minipuberty, decreased in childhood, and increased significantly from Tanner stages B1 to B3 (peak: B4) in females and from G1 to G3 (peak: G3) in males. Despite variations in menstruating females, inhibin B concentrations remained relatively constant after puberty, until becoming unmeasurable at menopause. Despite a modest decrease, the inhibin B concentration in males remained relatively high from puberty onwards. At any age, males had highest concentrations. Inhibin B standard deviation (SD) scores were lower in OC-users (median SD score = -0.88) than in non-users (SD score = 0.35), p < 0.001. In patients with Klinefelter syndrome, inhibin B concentrations spanned the reference range until around 15 years of age, where they decreased to subnormal or unmeasurable levels.
CONCLUSIONS: Valuable sex- and age-specific reference data for inhibin B concentrations were provided. In OC-users, decreased concentrations of inhibin B underlined the ovaries as the only place of inhibin B production. In patients with Klinefelter syndrome, the decline in inhibin B concentrations at puberty underlined the shift in regulation of inhibin B production at pubertal onset.
METHODS: Based on serum samples from 2707 healthy controls aged 0 to 80 years, sex- and age-specific reference ranges of inhibin B concentrations were constructed. Concentrations were evaluated according to pubertal development and use of oral contraceptives (OCs). Also, measurements from 42 patients with Klinefelter syndrome were included.
RESULTS: In both sexes, inhibin B concentrations were high during minipuberty, decreased in childhood, and increased significantly from Tanner stages B1 to B3 (peak: B4) in females and from G1 to G3 (peak: G3) in males. Despite variations in menstruating females, inhibin B concentrations remained relatively constant after puberty, until becoming unmeasurable at menopause. Despite a modest decrease, the inhibin B concentration in males remained relatively high from puberty onwards. At any age, males had highest concentrations. Inhibin B standard deviation (SD) scores were lower in OC-users (median SD score = -0.88) than in non-users (SD score = 0.35), p < 0.001. In patients with Klinefelter syndrome, inhibin B concentrations spanned the reference range until around 15 years of age, where they decreased to subnormal or unmeasurable levels.
CONCLUSIONS: Valuable sex- and age-specific reference data for inhibin B concentrations were provided. In OC-users, decreased concentrations of inhibin B underlined the ovaries as the only place of inhibin B production. In patients with Klinefelter syndrome, the decline in inhibin B concentrations at puberty underlined the shift in regulation of inhibin B production at pubertal onset.
摘要：
目的：根据性别描述一生中抑制素B的自然史，年龄,和青春期发育。
方法：基于2707名0至80岁健康对照者的血清样本，构建了抑制素B浓度的性别和年龄特异性参考范围。根据青春期发育和口服避孕药（OC）的使用评估浓度。此外，纳入了42例Klinefelter综合征患者的测量结果.
结果：在两性中，抑制素B浓度在青春期期间较高，在童年减少，女性从Tanner阶段B1到B3（峰值：B4）以及男性从G1到G3（峰值：G3）显着增加。尽管来月经的女性有所不同，抑制素B浓度在青春期后保持相对恒定，直到更年期变得无法衡量。尽管略有下降，从青春期开始，男性的抑制素B浓度仍然相对较高。在任何年龄,男性的浓度最高。OC使用者的InhibbinB标准差（SD）得分低于非使用者（SD得分=0.35），p<0.001。在Klinefelter综合征患者中,抑制素B浓度跨越参考范围，直到15岁左右，它们下降到低于正常或不可测量的水平。
结论：提供了抑制素B浓度的有价值的性别和年龄特异性参考数据。在OC用户中，抑制素B浓度降低强调卵巢是抑制素B产生的唯一场所。在Klinefelter综合征患者中,青春期抑制素B浓度的下降强调了青春期开始时抑制素B产生调节的转变。
方法：基于2707名0至80岁健康对照者的血清样本，构建了抑制素B浓度的性别和年龄特异性参考范围。根据青春期发育和口服避孕药（OC）的使用评估浓度。此外，纳入了42例Klinefelter综合征患者的测量结果.
结果：在两性中，抑制素B浓度在青春期期间较高，在童年减少，女性从Tanner阶段B1到B3（峰值：B4）以及男性从G1到G3（峰值：G3）显着增加。尽管来月经的女性有所不同，抑制素B浓度在青春期后保持相对恒定，直到更年期变得无法衡量。尽管略有下降，从青春期开始，男性的抑制素B浓度仍然相对较高。在任何年龄,男性的浓度最高。OC使用者的InhibbinB标准差（SD）得分低于非使用者（SD得分=0.35），p<0.001。在Klinefelter综合征患者中,抑制素B浓度跨越参考范围，直到15岁左右，它们下降到低于正常或不可测量的水平。
结论：提供了抑制素B浓度的有价值的性别和年龄特异性参考数据。在OC用户中，抑制素B浓度降低强调卵巢是抑制素B产生的唯一场所。在Klinefelter综合征患者中,青春期抑制素B浓度的下降强调了青春期开始时抑制素B产生调节的转变。
