Abstract：
UNASSIGNED: Non-alcoholic fatty liver disease (NAFLD) is known to be associated with metabolic syndrome of which diabetes is an important component. Although diabetes is a known risk factor for dementia, studies on the association between NAFLD and dementia still produce conflicting results. This study aimed to determine whether NAFLD would be a risk factor for the development of dementia in an elderly population.
UNASSIGNED: This study included 107,369 subjects aged ≥60 years in the Korean National Health Insurance Service-Senior cohort, entered in 2009 and followed up until 2015. NAFLD was diagnosed by calculating fatty liver index (FLI). Subjects were screened for dementia at baseline using a Korean Dementia Screening Questionnaire, and dementia was diagnosed using ICD-10 codes. Controls were randomly selected at a ratio of 1:5 from individuals who were at risk of becoming the case subjects at the time of selection.
UNASSIGNED: From 107,369 subjects, 65,690 stroke- and dementia-free subjects without chronic hepatitis B or C or excessive alcohol drinking were selected for evaluation. Having NAFLD, determined by FLI, was associated with increased risk of dementia development (adjusted odds ratio [AOR] 1.493; 95% confidence interval [CI] 1.214-1.836). The increased risk of dementia in NAFLD subjects was independent of type 2 diabetes (AOR 1.421; 95% CI 1.013-1.994, in subjects with diabetes: AOR 1.540; 95% CI 1.179- 2.010, in subjects without diabetes).
UNASSIGNED: In this population-based nested case-control study, having NAFLD increased the risk of dementia in elderly individuals, independent of accompanying diabetes.
UNASSIGNED: This study included 107,369 subjects aged ≥60 years in the Korean National Health Insurance Service-Senior cohort, entered in 2009 and followed up until 2015. NAFLD was diagnosed by calculating fatty liver index (FLI). Subjects were screened for dementia at baseline using a Korean Dementia Screening Questionnaire, and dementia was diagnosed using ICD-10 codes. Controls were randomly selected at a ratio of 1:5 from individuals who were at risk of becoming the case subjects at the time of selection.
UNASSIGNED: From 107,369 subjects, 65,690 stroke- and dementia-free subjects without chronic hepatitis B or C or excessive alcohol drinking were selected for evaluation. Having NAFLD, determined by FLI, was associated with increased risk of dementia development (adjusted odds ratio [AOR] 1.493; 95% confidence interval [CI] 1.214-1.836). The increased risk of dementia in NAFLD subjects was independent of type 2 diabetes (AOR 1.421; 95% CI 1.013-1.994, in subjects with diabetes: AOR 1.540; 95% CI 1.179- 2.010, in subjects without diabetes).
UNASSIGNED: In this population-based nested case-control study, having NAFLD increased the risk of dementia in elderly individuals, independent of accompanying diabetes.
摘要：
■已知非酒精性脂肪性肝病（NAFLD）与代谢综合征有关，糖尿病是代谢综合征的重要组成部分。虽然糖尿病是痴呆症的已知危险因素，关于NAFLD与痴呆相关性的研究仍产生相互矛盾的结果.这项研究旨在确定NAFLD是否会成为老年人群痴呆发展的危险因素。
■这项研究包括韩国国民健康保险服务高级队列中年龄≥60岁的107,369名受试者，进入2009年，并跟进到2015年。通过计算脂肪肝指数（FLI）诊断NAFLD。受试者在基线时使用韩国痴呆症筛查问卷进行痴呆症筛查，使用ICD-10代码诊断痴呆症。以1:5的比例从在选择时具有成为病例受试者的风险的个体中随机选择对照。
■来自107,369个科目，选择65,690名无慢性乙型或丙型肝炎或过量饮酒的无中风和痴呆受试者进行评估。有NAFLD，由FLI决定，与痴呆发展风险增加相关(校正比值比[AOR]1.493;95%置信区间[CI]1.214-1.836).NAFLD受试者痴呆风险的增加与2型糖尿病无关(AOR1.421;95%CI1.013-1.994,糖尿病受试者:AOR1.540;95%CI1.179-2.010,无糖尿病受试者)。
■在这项基于人群的嵌套病例对照研究中，患有NAFLD会增加老年人患痴呆症的风险，独立于伴随的糖尿病。
■这项研究包括韩国国民健康保险服务高级队列中年龄≥60岁的107,369名受试者，进入2009年，并跟进到2015年。通过计算脂肪肝指数（FLI）诊断NAFLD。受试者在基线时使用韩国痴呆症筛查问卷进行痴呆症筛查，使用ICD-10代码诊断痴呆症。以1:5的比例从在选择时具有成为病例受试者的风险的个体中随机选择对照。
■来自107,369个科目，选择65,690名无慢性乙型或丙型肝炎或过量饮酒的无中风和痴呆受试者进行评估。有NAFLD，由FLI决定，与痴呆发展风险增加相关(校正比值比[AOR]1.493;95%置信区间[CI]1.214-1.836).NAFLD受试者痴呆风险的增加与2型糖尿病无关(AOR1.421;95%CI1.013-1.994,糖尿病受试者:AOR1.540;95%CI1.179-2.010,无糖尿病受试者)。
■在这项基于人群的嵌套病例对照研究中，患有NAFLD会增加老年人患痴呆症的风险，独立于伴随的糖尿病。
