Abstract：
Noradrenaline (NA) and serotonin (5-HT) induce nociception and antinociception. This antagonistic effect can be explained by the dose and type of activated receptors. We investigated the existence of synergism between the noradrenergic and serotonergic systems during peripheral antinociception. The paw pressure test was performed in mice that had increased sensitivity by intraplantar injection of prostaglandin E2 (PGE2). Noradrenaline (80 ng) administered intraplantarly induced an antinociceptive effect, that was reversed by the administration of selective antagonists of serotoninergic receptors 5-HT1B isamoltan, 5-HT1D BRL15572, 5-HT2A ketanserin, 5-HT3 ondansetron, but not by selective receptor antagonist 5-HT7 SB-269970. The administration of escitalopram, a serotonin reuptake inhibitor, potentiated the antinociceptive effect at a submaximal dose of NA. These results, indicate the existence of synergism between the noradrenergic and serotonergic systems in peripheral antinociception in mice.
摘要：
去甲肾上腺素（NA）和5-羟色胺（5-HT）诱导伤害感受和抗伤害感受。这种拮抗作用可以通过激活受体的剂量和类型来解释。我们调查了在外周抗伤害作用期间去甲肾上腺素能和5-羟色胺能系统之间是否存在协同作用。在通过足底内注射前列腺素E2(PGE2)具有增加的敏感性的小鼠中进行爪压力测试。去甲肾上腺素（80ng）在植物内给药诱导了镇痛作用，通过给予5-HT1B异沙坦选择性拮抗剂逆转，5-HT1DBRL15572,5-HT2Aketanserin,5-HT3昂丹司琼,但不是通过选择性受体拮抗剂5-HT7SB-269970。艾司西酞普兰的管理，血清素再摄取抑制剂，在亚最大剂量的NA下增强了抗伤害作用。这些结果,表明小鼠外周抗伤害感受中去甲肾上腺素能和5-羟色胺能系统之间存在协同作用。
