PDF(Pubmed)
Abstract：
Epilepsy affects millions of people worldwide, and there is an urgent need to develop safe and effective therapeutic agents. Animal venoms contain diverse bioactive compounds like proteins, peptides, and small molecules, which may possess medicinal properties against epilepsy. In recent years, research has shown that venoms from various organisms such as spiders, ants, bees, wasps, and conus snails have anticonvulsant and antiepileptic effects by targeting specific receptors and ion channels. This review underscores the significance of purified proteins and toxins from these sources as potential therapeutic agents for epilepsy. In conclusion, this review emphasizes the valuable role of animal venoms as a natural resource for further exploration in epilepsy treatment research.
摘要：
癫痫影响着全世界数百万人，迫切需要开发安全有效的治疗剂。动物毒液含有多种生物活性化合物，如蛋白质，肽，和小分子，可能具有抗癫痫的药用特性。近年来,研究表明，毒液来自各种生物，如蜘蛛，蚂蚁,蜜蜂,黄蜂,和圆锥蜗牛通过靶向特定受体和离子通道而具有抗惊厥和抗癫痫作用。这篇综述强调了来自这些来源的纯化蛋白质和毒素作为癫痫潜在治疗剂的重要性。总之,这篇综述强调了动物毒液作为进一步探索癫痫治疗研究的自然资源的重要作用。
