PDF(Pubmed)
Abstract：
UNASSIGNED: Prior observational research has indicated a potential link between pediatric asthma and united airways disease (UAD). However, these findings could be subject to confounding factors and reverse causation. Therefore, our study utilizes Mendelian randomization (MR) method to further investigate the causal relationship between pediatric asthma and UAD.
UNASSIGNED: We conducted a comprehensive two-sample Mendelian randomization (MR) analysis to investigate the association between pediatric asthma and seven groups of UAD, including chronic sinusitis, chronic rhinitis, nasopharyngitis and pharyngitis, chronic diseases of tonsils and adenoids, chronic laryngitis and laryngotracheitis, chronic bronchitis, bronchiectasis, chronic obstructive pulmonary disease (COPD). The present study employed a range of methods for two-sample MR analysis, including inverse variance weighted (IVW), MR-Egger regression, Simple mode, weighted median, and weighted models. The conclusion of the MR analysis primarily relies on the IVW results, while other analytical methods are utilized as supplementary evidence to ensure result robustness in this MR analysis. And sensitivity analyses were conducted, including heterogeneity test, horizontal pleiotropy test, MR-PRESSO test, and leave-one-out analysis to validate the results.
UNASSIGNED: The results of the MR analysis indicate significant causal effects of pediatric asthma on chronic rhinitis, nasopharyngitis and pharyngitis (IVW: OR = 1.15, 95%CI: 1.05-1.26, p-value = 0.003), chronic diseases of tonsils and adenoids (IVW: OR = 1.07, 95%CI: 1.00-1.15, p-value = 0.038), chronic bronchitis (IVW: OR = 1.51, 95%CI: 1.42-1.62, p-value <0.001), bronchiectasis (IVW: OR = 1.51, 95%CI: (1.30-1.75), p-value <0.001), and COPD (IVW: OR = 1.43, 95%CI: 1.34-1.51, p-value <0.001). However, no significant causal association was observed between pediatric asthma and chronic sinusitis (IVW: OR = 1.00, 95%CI: 1.00-1.00, p-value = 0.085), chronic laryngitis and laryngotracheitis (IVW: OR = 1.05, 95%CI: 0.90-1.21, p-value = 0.558).
UNASSIGNED: Our findings support a potential causal relationship between pediatric asthma and UAD, suggesting that pediatric asthma may be a potential risk factor for various UAD.
UNASSIGNED: We conducted a comprehensive two-sample Mendelian randomization (MR) analysis to investigate the association between pediatric asthma and seven groups of UAD, including chronic sinusitis, chronic rhinitis, nasopharyngitis and pharyngitis, chronic diseases of tonsils and adenoids, chronic laryngitis and laryngotracheitis, chronic bronchitis, bronchiectasis, chronic obstructive pulmonary disease (COPD). The present study employed a range of methods for two-sample MR analysis, including inverse variance weighted (IVW), MR-Egger regression, Simple mode, weighted median, and weighted models. The conclusion of the MR analysis primarily relies on the IVW results, while other analytical methods are utilized as supplementary evidence to ensure result robustness in this MR analysis. And sensitivity analyses were conducted, including heterogeneity test, horizontal pleiotropy test, MR-PRESSO test, and leave-one-out analysis to validate the results.
UNASSIGNED: The results of the MR analysis indicate significant causal effects of pediatric asthma on chronic rhinitis, nasopharyngitis and pharyngitis (IVW: OR = 1.15, 95%CI: 1.05-1.26, p-value = 0.003), chronic diseases of tonsils and adenoids (IVW: OR = 1.07, 95%CI: 1.00-1.15, p-value = 0.038), chronic bronchitis (IVW: OR = 1.51, 95%CI: 1.42-1.62, p-value <0.001), bronchiectasis (IVW: OR = 1.51, 95%CI: (1.30-1.75), p-value <0.001), and COPD (IVW: OR = 1.43, 95%CI: 1.34-1.51, p-value <0.001). However, no significant causal association was observed between pediatric asthma and chronic sinusitis (IVW: OR = 1.00, 95%CI: 1.00-1.00, p-value = 0.085), chronic laryngitis and laryngotracheitis (IVW: OR = 1.05, 95%CI: 0.90-1.21, p-value = 0.558).
UNASSIGNED: Our findings support a potential causal relationship between pediatric asthma and UAD, suggesting that pediatric asthma may be a potential risk factor for various UAD.
摘要：
■先前的观察性研究表明，小儿哮喘与联合气道疾病（UAD）之间存在潜在的联系。然而,这些发现可能受到混杂因素和反向因果关系的影响.因此,我们的研究利用孟德尔随机化(MR)方法进一步研究小儿哮喘与UAD之间的因果关系.
■我们进行了全面的双样本孟德尔随机化（MR）分析，以调查小儿哮喘与七组UAD之间的关联，包括慢性鼻窦炎,慢性鼻炎,鼻咽炎和咽炎,扁桃体和腺样体的慢性疾病，慢性喉炎和喉支气管炎,慢性支气管炎,支气管扩张,慢性阻塞性肺疾病（COPD）。本研究采用了一系列方法进行双样本MR分析，包括逆方差加权(IVW)，MR-Egger回归，简单模式，加权中位数，和加权模型。MR分析的结论主要依赖于IVW结果，而其他分析方法被用作补充证据，以确保本次MR分析的结果稳健性。并进行了敏感性分析，包括异质性测试，水平多效性测试，MR-PRESSO试验,并留一法分析验证结果。
■MR分析结果表明儿童哮喘对慢性鼻炎有显著的因果关系，鼻咽炎和咽炎（IVW：OR=1.15，95CI：1.05-1.26，p值=0.003），扁桃体和腺样体的慢性疾病（IVW：OR=1.07，95CI：1.00-1.15，p值=0.038），慢性支气管炎（IVW：OR=1.51，95CI：1.42-1.62，p值<0.001），支气管扩张（IVW：OR=1.51，95CI：（1.30-1.75），p值<0.001)，和COPD（IVW：OR=1.43，95CI：1.34-1.51，p值<0.001）。然而,在小儿哮喘和慢性鼻窦炎之间没有观察到显著的因果关系(IVW:OR=1.00,95CI:1.00-1.00,p值=0.085),慢性喉炎和喉支气管炎（IVW：OR=1.05，95CI：0.90-1.21，p值=0.558）。
■我们的研究结果支持小儿哮喘和UAD之间的潜在因果关系，提示小儿哮喘可能是各种UAD的潜在危险因素。
■我们进行了全面的双样本孟德尔随机化（MR）分析，以调查小儿哮喘与七组UAD之间的关联，包括慢性鼻窦炎,慢性鼻炎,鼻咽炎和咽炎,扁桃体和腺样体的慢性疾病，慢性喉炎和喉支气管炎,慢性支气管炎,支气管扩张,慢性阻塞性肺疾病（COPD）。本研究采用了一系列方法进行双样本MR分析，包括逆方差加权(IVW)，MR-Egger回归，简单模式，加权中位数，和加权模型。MR分析的结论主要依赖于IVW结果，而其他分析方法被用作补充证据，以确保本次MR分析的结果稳健性。并进行了敏感性分析，包括异质性测试，水平多效性测试，MR-PRESSO试验,并留一法分析验证结果。
■MR分析结果表明儿童哮喘对慢性鼻炎有显著的因果关系，鼻咽炎和咽炎（IVW：OR=1.15，95CI：1.05-1.26，p值=0.003），扁桃体和腺样体的慢性疾病（IVW：OR=1.07，95CI：1.00-1.15，p值=0.038），慢性支气管炎（IVW：OR=1.51，95CI：1.42-1.62，p值<0.001），支气管扩张（IVW：OR=1.51，95CI：（1.30-1.75），p值<0.001)，和COPD（IVW：OR=1.43，95CI：1.34-1.51，p值<0.001）。然而,在小儿哮喘和慢性鼻窦炎之间没有观察到显著的因果关系(IVW:OR=1.00,95CI:1.00-1.00,p值=0.085),慢性喉炎和喉支气管炎（IVW：OR=1.05，95CI：0.90-1.21，p值=0.558）。
■我们的研究结果支持小儿哮喘和UAD之间的潜在因果关系，提示小儿哮喘可能是各种UAD的潜在危险因素。
