PDF(Pubmed)
Abstract：
UNASSIGNED: This meta-analysis aims to examine how effective ketamine is in the management of acute and preventing chronic post-thoracotomy pain by synthesizing the available research.
UNASSIGNED: A systematic literature search was conducted across PubMed, Scopus, and Cochrane Library till May 2023. Randomized Controlled Trials (RCT) examining the influence of ketamine on post-thoracotomy pain in adults were included. The intervention group included ketamine plus morphine, while the control group included morphine only. The outcome measures were opioid intake and pain scores at rest and on moving/coughing. Evidence quality was evaluated using the Cochrane Risk of Bias and GRADE assessment.
UNASSIGNED: Nine articles comprising 556 patients were selected for meta-analysis. The intervention group had a significant decrease in pain at rest (Std. Mean Difference (SMD = -0.60 with 95% CI [-0.83, -0.37]) and on movement/cough (SMD = -0.73 [-1.27, -0.18]) in the first postoperative days. Also, the ketamine group had lower opioid consumption (mg) in comparison with controls (SMD = -2.75 [-4.14, -1.36], p-value = 0.0001) in postoperative days 1-3. There was no data to assess the long-term effect of ketamine on chronic pain.
UNASSIGNED: This meta-analysis shows that ketamine use can lower acute pain levels and morphine use after thoracotomy. In the future, larger RCTs using standardized methods and assessing both short-term and long-term analgesic effects of ketamine are necessary to deepen the understanding of the issue.
UNASSIGNED: A systematic literature search was conducted across PubMed, Scopus, and Cochrane Library till May 2023. Randomized Controlled Trials (RCT) examining the influence of ketamine on post-thoracotomy pain in adults were included. The intervention group included ketamine plus morphine, while the control group included morphine only. The outcome measures were opioid intake and pain scores at rest and on moving/coughing. Evidence quality was evaluated using the Cochrane Risk of Bias and GRADE assessment.
UNASSIGNED: Nine articles comprising 556 patients were selected for meta-analysis. The intervention group had a significant decrease in pain at rest (Std. Mean Difference (SMD = -0.60 with 95% CI [-0.83, -0.37]) and on movement/cough (SMD = -0.73 [-1.27, -0.18]) in the first postoperative days. Also, the ketamine group had lower opioid consumption (mg) in comparison with controls (SMD = -2.75 [-4.14, -1.36], p-value = 0.0001) in postoperative days 1-3. There was no data to assess the long-term effect of ketamine on chronic pain.
UNASSIGNED: This meta-analysis shows that ketamine use can lower acute pain levels and morphine use after thoracotomy. In the future, larger RCTs using standardized methods and assessing both short-term and long-term analgesic effects of ketamine are necessary to deepen the understanding of the issue.
摘要：
■这项荟萃分析旨在通过综合现有研究来检查氯胺酮在急性和预防慢性开胸术后疼痛的管理中的有效性。
■在PubMed，Scopus,和科克伦图书馆到2023年5月。包括研究氯胺酮对成人开胸术后疼痛影响的随机对照试验（RCT）。干预组包括氯胺酮加吗啡，而对照组仅包括吗啡。结果指标是阿片类药物摄入量和休息和移动/咳嗽时的疼痛评分。使用Cochrane偏差风险和等级评估来评估证据质量。
■选择包含556名患者的9篇文章进行荟萃分析。干预组静息时疼痛显着降低（Std。术后第一天的平均差（SMD=-0.60，95%CI[-0.83，-0.37]）和运动/咳嗽（SMD=-0.73[-1.27，-0.18]）。此外，与对照组相比，氯胺酮组的阿片类药物消费量（mg）较低（SMD=-2.75[-4.14，-1.36]，p值=0.0001）在术后第1-3天。没有数据来评估氯胺酮对慢性疼痛的长期影响。
■这项荟萃分析表明，使用氯胺酮可以降低开胸手术后的急性疼痛水平和吗啡使用。在未来,使用标准化方法进行更大规模的随机对照试验,并评估氯胺酮的短期和长期镇痛效果,对于加深对该问题的理解是必要的.
■在PubMed，Scopus,和科克伦图书馆到2023年5月。包括研究氯胺酮对成人开胸术后疼痛影响的随机对照试验（RCT）。干预组包括氯胺酮加吗啡，而对照组仅包括吗啡。结果指标是阿片类药物摄入量和休息和移动/咳嗽时的疼痛评分。使用Cochrane偏差风险和等级评估来评估证据质量。
■选择包含556名患者的9篇文章进行荟萃分析。干预组静息时疼痛显着降低（Std。术后第一天的平均差（SMD=-0.60，95%CI[-0.83，-0.37]）和运动/咳嗽（SMD=-0.73[-1.27，-0.18]）。此外，与对照组相比，氯胺酮组的阿片类药物消费量（mg）较低（SMD=-2.75[-4.14，-1.36]，p值=0.0001）在术后第1-3天。没有数据来评估氯胺酮对慢性疼痛的长期影响。
■这项荟萃分析表明，使用氯胺酮可以降低开胸手术后的急性疼痛水平和吗啡使用。在未来,使用标准化方法进行更大规模的随机对照试验,并评估氯胺酮的短期和长期镇痛效果,对于加深对该问题的理解是必要的.
