Mesenchymal-epithelial transition factor exon 14 skipping mutation-positive granulocyte colony-stimulating factor-producing lung adenocarcinoma mimicking lung abscess: A case report.

间充质 - 上皮转化因子外显子 14 跳跃突变阳性粒细胞集落刺激因子产生模拟肺脓肿的肺腺癌 ： 一例报告。

• 发表时间: 2024 Jun
• 来源期刊: Respirol Case Rep
• DOI: 10.1002/rcr2.1419
• PMID: 38919814
• 文章类型: Case Reports
• 作者列表: Izumiya Y,Odaka H,Kikuchi T,Takita Y,Tokairin T

关键词: G‐CSF‐producing tumour; MET exon 14; lung abscess; lung adenocarcinoma; sterile lung abscess; tepotinib

Abstract

Granulocyte colony-stimulating factor (G-CSF)-producing lung tumours are rare, with their imaging features and effective treatments remaining elusive. Similarly, mesenchymal-epithelial transition (MET) exon 14 skipping mutations are also uncommon. Herein, we report a case of G-CSF-producing lung adenocarcinoma positive for a MET exon 14 skipping mutation, mimicking lung abscess. A 61-year-old man presented with cough and high fever. Contrast-enhanced chest computed tomography revealed a mass with a cavity and internal fluid accumulation. The patient initially underwent diagnostic treatment for a lung abscess but was ultimately diagnosed with lung adenocarcinoma positive for a MET exon 14 skipping mutation. Following tepotinib therapy, the primary lesion shrank, and serum G-CSF levels decreased, leading to a diagnosis of G-CSF-producing lung cancer. G-CSF-producing lung tumours can present imaging findings that mimic lung abscesses. Tepotinib therapy may be effective for patients with MET exon 14 skipping mutation, including those with G-CSF-producing lung cancer.

摘要

产生粒细胞集落刺激因子（G-CSF）的肺肿瘤很少见，他们的成像特征和有效的治疗仍然难以捉摸。同样，间充质-上皮转化（MET）外显子14跳跃突变也不常见。在这里，我们报道一例产生G-CSF的肺腺癌MET第14外显子跳跃突变阳性，模仿肺脓肿。一名61岁男子出现咳嗽和高烧。对比增强胸部计算机断层扫描显示肿块有腔和内部液体积聚。患者最初接受肺脓肿的诊断治疗，但最终被诊断为MET外显子14跳跃突变阳性的肺腺癌。在替替尼治疗后，原发病变缩小,血清G-CSF水平下降，导致产生G-CSF的肺癌的诊断。产生G-CSF的肺肿瘤可以呈现模拟肺脓肿的影像学发现。Tepotinib治疗可能对MET外显子14跳跃突变的患者有效，包括那些产生G-CSF的肺癌。