PDF(Pubmed)
Abstract：
When patients with hemophilia and allied disorders (von Willebrand disease and other congenital bleeding disorders) do not receive adequate primary hematologic prophylaxis from infancy, their joints will suffer knee joint degeneration; when such joint degeneration becomes very advanced (painful and disabling) despite previous conservative treatment, the only way to alleviate the problem will be to implant a primary total knee arthroplasty (TKA). The literature has shown that twenty years after implantation, 71% of primary TKAs are still functional; on the other hand, 18% have to be revised as a consequence of periprosthetic joint infection (PJI). The main causes of revision total knee arthroplasty are PJI and aseptic loosening (39% each).
摘要：
当血友病和相关疾病（血管性血友病和其他先天性出血性疾病）的患者未从婴儿期接受足够的主要血液学预防时，他们的关节将遭受膝关节退化;当这种关节退化变得非常先进（疼痛和致残），尽管以前的保守治疗，缓解这一问题的唯一方法是植入初次全膝关节置换术(TKA).文献显示，植入后二十年，71%的主要TKA仍然有效；另一方面，由于假体周围关节感染（PJI），必须修改18％。翻修全膝关节置换术的主要原因是PJI和无菌性松动(各39%)。
