PDF(Pubmed)
Abstract：
UNASSIGNED: The human oral microbiome may play a role in the development of oral squamous cell carcinoma. The aim of this scoping review was to examine microbial diversity and differences in the composition of the oral microbiome between OSCC patients and healthy controls.
UNASSIGNED: A literature search (in PubMed and Embase.com) was performed on January 9, 2023. The outcome variables used from the included studies of this review were alpha- and beta diversity and oral microbiome composition profiles for each taxonomic level (phylum-, class-, order-, genus- and species level).
UNASSIGNED: Thirteen out of 423 studies were included in this review compromising 1,677 subjects, of which 905 (54.0%) were OSCC patients and 772 (46.0%) were healthy controls. Most studies found a higher alpha diversity in the OSCC patient group and significantly different beta diversities between OSCC patient samples and healthy control samples. Studies reported more abundant Fusobacteria (on phylum level), Fusobacterium (on genus level), Fusobacterium nucleatum, Porphyromonas endodontalis and Prevotella intermedia (on species level) in OSCC patients. The healthy control group had more abundant Actinobacteria (on phylum level), Streptococcus and Veilonella (on genus level) and Veilonella parvula (on species level) according to most studies.
UNASSIGNED: Our findings show differences in oral microbiome diversity and composition in OSCC patients. Clinical implications demand continuing study. Development of internationally accepted standard procedures for oral sample collection and oral microbiota analysis is needed for more conclusive and clinically relevant comparisons in future research.
UNASSIGNED: A literature search (in PubMed and Embase.com) was performed on January 9, 2023. The outcome variables used from the included studies of this review were alpha- and beta diversity and oral microbiome composition profiles for each taxonomic level (phylum-, class-, order-, genus- and species level).
UNASSIGNED: Thirteen out of 423 studies were included in this review compromising 1,677 subjects, of which 905 (54.0%) were OSCC patients and 772 (46.0%) were healthy controls. Most studies found a higher alpha diversity in the OSCC patient group and significantly different beta diversities between OSCC patient samples and healthy control samples. Studies reported more abundant Fusobacteria (on phylum level), Fusobacterium (on genus level), Fusobacterium nucleatum, Porphyromonas endodontalis and Prevotella intermedia (on species level) in OSCC patients. The healthy control group had more abundant Actinobacteria (on phylum level), Streptococcus and Veilonella (on genus level) and Veilonella parvula (on species level) according to most studies.
UNASSIGNED: Our findings show differences in oral microbiome diversity and composition in OSCC patients. Clinical implications demand continuing study. Development of internationally accepted standard procedures for oral sample collection and oral microbiota analysis is needed for more conclusive and clinically relevant comparisons in future research.
摘要：
■人类口腔微生物组可能在口腔鳞状细胞癌的发展中起作用。这项范围审查的目的是检查OSCC患者和健康对照之间的微生物多样性和口腔微生物组组成差异。
■于2023年1月9日进行了文献检索（在PubMed和Embase.com中）。从这篇综述的纳入研究中使用的结果变量是每个分类水平的α-和β多样性和口腔微生物组组成谱(phylum,class-,order-,属和物种水平)。
■423项研究中有13项纳入了这篇综述，涉及1,677名受试者。其中OSCC患者905例(54.0%),健康对照772例(46.0%).大多数研究发现OSCC患者组中的α多样性较高,并且OSCC患者样品和健康对照样品之间的β多样性显著不同。研究报告了更丰富的镰刀菌（门水平），梭杆菌（属水平），具核梭杆菌,OSCC患者的牙髓卟啉单胞菌和中间的Prevotella（在物种水平上）。健康对照组放线菌较丰富（门水平），根据大多数研究，链球菌和韦洛氏菌（属水平）和韦洛氏菌（在物种水平）。
■我们的研究结果表明OSCC患者口腔微生物组多样性和组成存在差异。临床意义需要继续研究。需要开发国际公认的口腔样本收集和口腔微生物群分析的标准程序，以便在未来的研究中进行更确凿和临床相关的比较。
■于2023年1月9日进行了文献检索（在PubMed和Embase.com中）。从这篇综述的纳入研究中使用的结果变量是每个分类水平的α-和β多样性和口腔微生物组组成谱(phylum,class-,order-,属和物种水平)。
■423项研究中有13项纳入了这篇综述，涉及1,677名受试者。其中OSCC患者905例(54.0%),健康对照772例(46.0%).大多数研究发现OSCC患者组中的α多样性较高,并且OSCC患者样品和健康对照样品之间的β多样性显著不同。研究报告了更丰富的镰刀菌（门水平），梭杆菌（属水平），具核梭杆菌,OSCC患者的牙髓卟啉单胞菌和中间的Prevotella（在物种水平上）。健康对照组放线菌较丰富（门水平），根据大多数研究，链球菌和韦洛氏菌（属水平）和韦洛氏菌（在物种水平）。
■我们的研究结果表明OSCC患者口腔微生物组多样性和组成存在差异。临床意义需要继续研究。需要开发国际公认的口腔样本收集和口腔微生物群分析的标准程序，以便在未来的研究中进行更确凿和临床相关的比较。
