PDF(Pubmed)
Abstract：
Early initiation of enteral nutrition (EN) in pediatrics has been associated with improved clinical outcomes in critically ill pediatric patients. This research study aimed to measure the effect of early EN in intubated children on the length of stay (LOS) and days of mechanical ventilation (DMV). A retrospective cohort observational study was performed on patients admitted to the pediatric intensive care unit (PICU). We gathered the information from available medical records. Our exposure variable was EN, which can be classified as either early-onset (less than 72 hours following PICU admission) or late-onset (greater than or equal to 72 hours following PICU admission). The response variables were LOS defined as the period of time from either hospital or PICU admission to the time of hospital discharge and DMV defined as the length of time from endotracheal intubation to successful extubation. Late EN was associated with an increase in both hospital LOS consisting of 9.82 days and PICU LOS consisting of 5.89 days, and DMV consisting of 3.92 days compared with those patients receiving early EN. In addition, the disruption of EN was also associated with an increased hospital LOS consisting of 10.7 days. Patients in the PICU, undergoing mechanical ventilation, who received late EN have an increased risk of unfavorable outcomes consisting of prolonged hospital LOS, PICU-LOS, and DMV which may be further aggravated by any disruption of EN.
摘要：
儿科早期开始肠内营养（EN）与危重儿科患者临床结局的改善有关。这项研究旨在测量插管儿童早期EN对住院时间（LOS）和机械通气天数（DMV）的影响。对入住儿科重症监护病房（PICU）的患者进行了一项回顾性队列观察性研究。我们从现有的医疗记录中收集了信息。我们的暴露变量是EN，可以分为早发性（PICU入院后少于72小时）或晚发性（PICU入院后大于或等于72小时）。反应变量的LOS定义为从医院或PICU入院到出院时间的时间段，DMV定义为从气管插管到成功拔管的时间长度。晚期EN与由9.82天组成的医院LOS和由5.89天组成的PICULOS的增加有关，与接受早期EN的患者相比，DMV为3.92天。此外,EN中断还与10.7天的医院LOS增加相关.PICU的病人,进行机械通气，接受晚期EN的患者出现不良结局的风险增加，包括延长的医院LOS，PICU-LOS,和DMV，可能因EN的任何中断而进一步恶化。
