PDF(Pubmed)
Abstract：
Foxp3+ regulatory T cells (Foxp3+ Treg) play a role in regulating various types of tumors, but uncertainty still exists regarding the exact mechanism underlying Foxp3+ Treg activation in gastrointestinal malignancies. As of now, research has shown that Foxp3+ Treg expression, altered glucose metabolism, or a hypoxic tumor microenvironment all affect Foxp3+ Treg function in the bodies of tumor patients. Furthermore, it has been demonstrated that post-translational modifications are essential for mature Foxp3 to function properly. Additionally, a considerable number of non-coding RNAs (ncRNAs) have been implicated in the activation of the Foxp3 signaling pathway. These mechanisms regulating Foxp3 may one day serve as potential therapeutic targets for gastrointestinal malignancies. This review primarily focuses on the properties and capabilities of Foxp3 and Foxp3+Treg. It emphasizes the advancement of research on the regulatory mechanisms of Foxp3 in different malignant tumors of the digestive system, providing new insights for the exploration of anticancer treatments.
摘要：
Foxp3+调节性T细胞(Foxp3+Treg)在调节各种类型的肿瘤中起作用,但是关于Foxp3+Treg在胃肠道恶性肿瘤中激活的确切机制仍然存在不确定性。截至目前,研究表明，Foxp3+Treg表达，改变葡萄糖代谢，或缺氧的肿瘤微环境都会影响肿瘤患者体内的Foxp3+Treg功能。此外，已经证明,翻译后修饰对于成熟的Foxp3正常发挥功能是必需的。此外,大量的非编码RNA(ncRNA)与Foxp3信号通路的激活有关。这些调节Foxp3的机制有一天可能成为胃肠道恶性肿瘤的潜在治疗靶标。这篇综述主要集中在Foxp3和Foxp3+Treg的特性和功能上。强调Foxp3在消化系统不同恶性肿瘤中的调控机制研究进展,为探索抗癌治疗提供新的见解。
