PDF(Pubmed)
Abstract：
UNASSIGNED: The inflammatory response is a pivotal factor in accelerating the progression of atherosclerosis. The high-sensitivity C-reactive protein-to-albumin ratio (CAR) has emerged as a novel marker of systemic inflammation. However, few studies have shown the CAR to be a promising prognostic marker for carotid atherosclerotic disease. This study aimed to analyse the predictive role of the CAR in carotid atherosclerotic disease.
UNASSIGNED: This community-based cohort study recruited 2003 participants from the Rose asymptomatic IntraCranial Artery Stenosis (RICAS) study who were free of stroke or transient ischemic attack. Carotid atherosclerotic plaques and their stability were identified via carotid ultrasound. Logistic regression models were utilized to investigate the association between CAR and the presence of carotid atherosclerotic plaques.
UNASSIGNED: The prevalence of carotid atherosclerotic plaques was 38.79% in this study. After adjusting for clinical risk factors, including sex, age, dyslipidemia, hypertension, diabetes mellitus (DM), and smoking and drinking habits, a high CAR-level was independently associated with carotid plaque (odds ratio [OR] of upper: 1.46, 95% confidence interval [CI]: 1.13-1.90, P = 0.004; P for trend = 0.011). The highest CAR tertile was still significantly associated with carotid plaques among middle-aged (40-64 years) or female participants. Notably, an elevated CAR may be an independent risk factor for vulnerable carotid plaques (OR of upper: 2.06, 95% CI: 1.42-2.98, P < 0.001; P for trend <0.001).
UNASSIGNED: A high CAR may be correlated with a high risk of carotid plaques, particularly among mildly aged adults (40-64 years) or females. Importantly, the CAR may be associated with vulnerable carotid plaques, suggesting that the CAR may be a new indicator for stroke prevention.
UNASSIGNED: This community-based cohort study recruited 2003 participants from the Rose asymptomatic IntraCranial Artery Stenosis (RICAS) study who were free of stroke or transient ischemic attack. Carotid atherosclerotic plaques and their stability were identified via carotid ultrasound. Logistic regression models were utilized to investigate the association between CAR and the presence of carotid atherosclerotic plaques.
UNASSIGNED: The prevalence of carotid atherosclerotic plaques was 38.79% in this study. After adjusting for clinical risk factors, including sex, age, dyslipidemia, hypertension, diabetes mellitus (DM), and smoking and drinking habits, a high CAR-level was independently associated with carotid plaque (odds ratio [OR] of upper: 1.46, 95% confidence interval [CI]: 1.13-1.90, P = 0.004; P for trend = 0.011). The highest CAR tertile was still significantly associated with carotid plaques among middle-aged (40-64 years) or female participants. Notably, an elevated CAR may be an independent risk factor for vulnerable carotid plaques (OR of upper: 2.06, 95% CI: 1.42-2.98, P < 0.001; P for trend <0.001).
UNASSIGNED: A high CAR may be correlated with a high risk of carotid plaques, particularly among mildly aged adults (40-64 years) or females. Importantly, the CAR may be associated with vulnerable carotid plaques, suggesting that the CAR may be a new indicator for stroke prevention.
摘要：
■炎症反应是加速动脉粥样硬化进展的关键因素。高敏C反应蛋白与白蛋白之比（CAR）已成为全身性炎症的新型标志物。然而,很少有研究表明CAR是颈动脉粥样硬化疾病的一个有前景的预后标志物.本研究旨在分析CAR在颈动脉粥样硬化疾病中的预测作用。
■这项基于社区的队列研究招募了2003年Rose无症状颅内动脉狭窄（RICAS）研究的参与者，他们没有中风或短暂性脑缺血发作。颈动脉超声检查颈动脉粥样硬化斑块及其稳定性。采用Logistic回归模型研究CAR与颈动脉粥样硬化斑块的关系。
■本研究颈动脉粥样硬化斑块的患病率为38.79%。在调整临床危险因素后，包括性,年龄,血脂异常,高血压,糖尿病（DM），吸烟和饮酒习惯，高CAR水平与颈动脉斑块独立相关(比值比[OR]上限:1.46,95%置信区间[CI]:1.13~1.90,P=0.004;趋势P=0.011).在中年（40-64岁）或女性参与者中，最高的CAR三元仍然与颈动脉斑块显着相关。值得注意的是,CAR升高可能是颈动脉易损斑块的独立危险因素(OR:2.06,95%CI:1.42-2.98,P<0.001;趋势P<0.001).
■高CAR可能与颈动脉斑块的高风险相关，特别是在轻度成年人（40-64岁）或女性中。重要的是,CAR可能与易损的颈动脉斑块有关，表明CAR可能是预防中风的新指标。
■这项基于社区的队列研究招募了2003年Rose无症状颅内动脉狭窄（RICAS）研究的参与者，他们没有中风或短暂性脑缺血发作。颈动脉超声检查颈动脉粥样硬化斑块及其稳定性。采用Logistic回归模型研究CAR与颈动脉粥样硬化斑块的关系。
■本研究颈动脉粥样硬化斑块的患病率为38.79%。在调整临床危险因素后，包括性,年龄,血脂异常,高血压,糖尿病（DM），吸烟和饮酒习惯，高CAR水平与颈动脉斑块独立相关(比值比[OR]上限:1.46,95%置信区间[CI]:1.13~1.90,P=0.004;趋势P=0.011).在中年（40-64岁）或女性参与者中，最高的CAR三元仍然与颈动脉斑块显着相关。值得注意的是,CAR升高可能是颈动脉易损斑块的独立危险因素(OR:2.06,95%CI:1.42-2.98,P<0.001;趋势P<0.001).
■高CAR可能与颈动脉斑块的高风险相关，特别是在轻度成年人（40-64岁）或女性中。重要的是,CAR可能与易损的颈动脉斑块有关，表明CAR可能是预防中风的新指标。
