PDF(Pubmed)
Abstract：
UNASSIGNED: Ventilator-associated pneumonia (VAP) is a nosocomial infection associated with high morbidity and mortality. This study was undertaken to monitor the trend of the demographical details, comorbid conditions, bacterial etiological agents, and their antibiogram causing VAP in adults in the year 2008, 2013 and 2018.
UNASSIGNED: A retrospective study conducted at the Department of Microbiology, Hospital Infection control and Quality Control at a tertiary care teaching hospital. All the adult patients with more than 48 h of the mechanical ventilator with endotracheal intubation with Clinical Pulmonary infection Score >6 with suspicion of VAP were included in the study at a difference of 5 years, i.e., 2008, 2013, and 2018.
UNASSIGNED: A total of 338 patients were included in the study, of which males accounted for more than two-third of the patients studied. Nearly 45% of the patients belonged to geriatric (>60 years) age group. The most common comorbid conditions were chronic obstructive pulmonary disease, hypertension and diabetes mellitus. Among the gram-negative isolates, Klebsiella pneumoniae, Acinetobacter species, and Pseudomonas aeruginosa were the most common. There is an emergence of resistance to most commonly administered antimicrobial agents like aminoglycosides, levofloxacin, piperacillin/tazobactum, and carbapenems during the study period.
UNASSIGNED: This is a ten-year study on the antibiotic resistance pattern of organisms causing VAP. As far as the authors are aware, this is the first study addressing the pattern of change in drug resistance in the organisms causing VAP over a decade. The emergence of multi-drug resistant (MDR) MDR pathogens, especially in intensive care unit (ICU), is a great concern for the intensivist and infection control physicians. Preventive measures need to be undertaken to control the spread of these pathogens to the patients in the ICU.
UNASSIGNED: A retrospective study conducted at the Department of Microbiology, Hospital Infection control and Quality Control at a tertiary care teaching hospital. All the adult patients with more than 48 h of the mechanical ventilator with endotracheal intubation with Clinical Pulmonary infection Score >6 with suspicion of VAP were included in the study at a difference of 5 years, i.e., 2008, 2013, and 2018.
UNASSIGNED: A total of 338 patients were included in the study, of which males accounted for more than two-third of the patients studied. Nearly 45% of the patients belonged to geriatric (>60 years) age group. The most common comorbid conditions were chronic obstructive pulmonary disease, hypertension and diabetes mellitus. Among the gram-negative isolates, Klebsiella pneumoniae, Acinetobacter species, and Pseudomonas aeruginosa were the most common. There is an emergence of resistance to most commonly administered antimicrobial agents like aminoglycosides, levofloxacin, piperacillin/tazobactum, and carbapenems during the study period.
UNASSIGNED: This is a ten-year study on the antibiotic resistance pattern of organisms causing VAP. As far as the authors are aware, this is the first study addressing the pattern of change in drug resistance in the organisms causing VAP over a decade. The emergence of multi-drug resistant (MDR) MDR pathogens, especially in intensive care unit (ICU), is a great concern for the intensivist and infection control physicians. Preventive measures need to be undertaken to control the spread of these pathogens to the patients in the ICU.
摘要：
■呼吸机相关性肺炎（VAP）是一种与高发病率和死亡率相关的医院感染。这项研究是为了监测人口统计细节的趋势，合并症条件，细菌病原体，以及它们的抗菌谱在2008年、2013年和2018年引起成人VAP。
■在微生物学系进行的一项回顾性研究，三级护理教学医院的医院感染控制和质量控制。将机械呼吸机气管插管48h以上临床肺部感染评分>6分怀疑VAP的成年患者纳入研究，差异5年。即，2008年、2013年和2018年。
■共338名患者被纳入研究，其中男性占研究患者的三分之二以上。近45%的患者属于老年(>60岁)年龄组。最常见的合并症是慢性阻塞性肺疾病，高血压和糖尿病。在革兰氏阴性分离株中，肺炎克雷伯菌,不动杆菌属,铜绿假单胞菌最常见。对最常用的抗微生物剂如氨基糖苷类药物产生耐药性，左氧氟沙星,哌拉西林/他唑巴司，和碳青霉烯类抗生素在研究期间。
■这是一项为期十年的研究，涉及引起VAP的生物的抗生素抗性模式。据作者所知，这是10年来首次研究引起VAP的生物体耐药性变化模式.多药耐药（MDR）MDR病原体的出现，特别是在重症监护病房(ICU),是重症医师和感染控制医师非常关注的问题。需要采取预防措施来控制这些病原体向ICU患者的传播。
■在微生物学系进行的一项回顾性研究，三级护理教学医院的医院感染控制和质量控制。将机械呼吸机气管插管48h以上临床肺部感染评分>6分怀疑VAP的成年患者纳入研究，差异5年。即，2008年、2013年和2018年。
■共338名患者被纳入研究，其中男性占研究患者的三分之二以上。近45%的患者属于老年(>60岁)年龄组。最常见的合并症是慢性阻塞性肺疾病，高血压和糖尿病。在革兰氏阴性分离株中，肺炎克雷伯菌,不动杆菌属,铜绿假单胞菌最常见。对最常用的抗微生物剂如氨基糖苷类药物产生耐药性，左氧氟沙星,哌拉西林/他唑巴司，和碳青霉烯类抗生素在研究期间。
■这是一项为期十年的研究，涉及引起VAP的生物的抗生素抗性模式。据作者所知，这是10年来首次研究引起VAP的生物体耐药性变化模式.多药耐药（MDR）MDR病原体的出现，特别是在重症监护病房(ICU),是重症医师和感染控制医师非常关注的问题。需要采取预防措施来控制这些病原体向ICU患者的传播。
