PDF(Pubmed)
Abstract：
Human studies have shown the anticancer effects of dietary isothiocyanates (ITCs), but there are some inconsistencies, and more evidence supports that such anticancer effect is from higher doses of ITCs. The inconsistencies found in epidemiological studies may be due to many factors, including the biphasic dose-response (so called hormetic effect) of ITCs, which was found to be more profound under hypoxia conditions. In this comprehensive review, we aim to shed light on the intriguing synergistic interactions between dietary ITCs, focusing on sulforaphane (SFN) and various anticancer drugs. Our exploration is motivated by the potential of these combinations to enhance cancer management strategies. While the anticancer properties of ITCs have been recognized, our review delves deeper into understanding the mechanisms and emphasizing the significance of the hormetic effect of ITCs, characterized by lower doses stimulating both normal cells and cancer cells, whereas higher doses are toxic to cancer cells and inhibit their growth. We have examined a spectrum of studies unraveling the multifaceted interaction and combinational effects of ITCs with anticancer agents. Our analysis reveals the potential of these synergies to augment therapeutic efficacy, mitigate chemoresistance, and minimize toxic effects, thereby opening avenues for therapeutic innovation. The review will provide insights into the underlying mechanisms of action, for example, by spotlighting the pivotal role of Nrf2 and antioxidant enzymes in prevention. Finally, we glimpse ongoing research endeavors and contemplate future directions in this dynamic field. We believe that our work contributes valuable perspectives on nutrition and cancer and holds promise for developing novel and optimized therapeutic strategies.
摘要：
人体研究表明，饮食中异硫氰酸酯（ITC）的抗癌作用，但是有一些不一致之处，更多的证据支持这种抗癌作用来自于更高剂量的ITC。在流行病学研究中发现的不一致可能是由于许多因素，包括ITC的双相剂量-反应(所谓的停滞效应)，这在缺氧条件下被发现更深刻。在这次全面审查中，我们的目标是阐明饮食ITC之间有趣的协同相互作用，专注于萝卜硫素（SFN）和各种抗癌药物。我们的探索受到这些组合增强癌症管理策略的潜力的推动。虽然已经认识到ITCs的抗癌特性，我们的综述更深入地理解了ITC的机制，并强调了ITC效应的重要性，以低剂量刺激正常细胞和癌细胞为特征，而更高的剂量对癌细胞有毒性并抑制其生长。我们已经研究了一系列研究，揭示了ITC与抗癌剂的多方面相互作用和组合作用。我们的分析揭示了这些协同作用增强治疗功效的潜力，减轻化学抗性，并尽量减少毒性作用，从而为治疗创新开辟了道路。审查将提供对基本行动机制的见解，例如,通过突出Nrf2和抗氧化酶在预防中的关键作用。最后,我们瞥见正在进行的研究努力，并思考这个动态领域的未来方向。我们相信，我们的工作为营养和癌症提供了宝贵的观点，并有望开发新的和优化的治疗策略。
