UNASSIGNED: The three groups all reached a stable peak at 6 months, and the average levels of the three groups were 49.21, 42.50 and 43.025 nmol/L, respectively. The average levels of group A were higher than those of group B and group C (P < 0.001). The mean values of serum 25(OH)D measured by LC-MS and CLIA in 42 healthy adults were 45.32 nmol/L and 49.88 nmol/L, respectively, and the mean values of 25(OH)D measured by LC-MS in capillary blood were 52.03 nmol/L, and the difference was statistically significant (P < 0.001). Pearson correlation analysis showed that the linear fitting formula of scatter data was as follows: venous 25(OH)D concentration (nmol/L) = 1.105 * capillary 25(OH)D concentration -7.532 nmol/L, R2 = 0.625. Good agreement was observed between venous and corrected capillary 25(OH)D levels in clinical diagnosis (Kappa value 0.75). The adjusted serum 25(OH)D in capillary blood had a high clinical predictive value.
UNASSIGNED: The agreement between the two methods is good when the measured 25(OH)D level is higher. Standardized capillary blood chemiluminescence method can be used for 25(OH)D detection.
■三组均在6个月时达到稳定高峰,三组的平均水平分别为49.21、42.50和43.025nmol/L,分别。A组的平均水平高于B组和C组(P<0.001)。LC-MS和CLIA检测42例健康成人血清25(OH)D平均值分别为45.32nmol/L和49.88nmol/L,分别,LC-MS测定毛细血管血中25(OH)D的平均值为52.03nmol/L,差异有统计学意义(P<0.001)。Pearson相关分析表明,散点图数据的线性拟合公式为:静脉25(OH)D浓度(nmol/L)=1.105*毛细血管25(OH)D浓度-7.532nmol/L,R2=0.625。在临床诊断中,静脉和校正的毛细血管25(OH)D水平之间观察到良好的一致性(Kappa值0.75)。毛细血管血中调整的血清25(OH)D具有较高的临床预测价值。
■当测得的25(OH)D水平较高时,两种方法之间的一致性很好。标准化毛细管血液化学发光法可用于25(OH)D的检测。