PDF(Pubmed)
Abstract：
Obesity, characterized by excessive storage of lipids, has become a global pandemic with high incidence levels, and its forecast is not encouraging. Currently, there are different strategies to treat obesity; however, these conventional methods have various limitations. Lifestyle changes may result in poor outcomes due to the complexity of obesity causes, pharmaceutic treatments produce severe side effects, and bariatric surgery is highly invasive. In the search for alternative treatments to fight obesity, transdermal drug delivery systems of anti-obesogenic molecules have gained particular attention. However, the diffusion of molecules through the skin is the main drawback due to the characteristics of different layers of the skin, principally the stratum corneum and its barrier-like behavior. In this sense, microneedles patches (MP) have emerged to overcome this limitation by piercing the skin and allowing drug delivery inside the body. Although MP have been studied for some years, it was not until about 2017 that their potential as anti-obesogenic treatment was reported. This article aims to summarize and analyze the strategies employed to produce MP and to embed the active molecules against obesity. Special attention is focused on the microneedle\'s material, geometry, array, and additional delivery strategies, like nanoencapsulation. MP are a promising tool to develop an easy-access treatment, avoiding the digestive tract and with the capacity to enhance the anti-obesogenic activity by delivering one or more active molecules.
摘要：
肥胖,以过度储存脂质为特征，已经成为发病率高的全球流行病，它的预测并不令人鼓舞。目前,有不同的策略来治疗肥胖;然而，这些常规方法具有各种局限性。由于肥胖原因的复杂性，生活方式的改变可能会导致不良结果。药物治疗会产生严重的副作用，减肥手术是高度侵入性的。在寻找替代治疗肥胖的方法时，抗生性分子的经皮药物递送系统已获得特别关注。然而,由于皮肤不同层的特性，分子通过皮肤的扩散是主要缺点，主要是角质层及其屏障样行为。在这个意义上,已经出现了微针贴剂(MP)通过刺穿皮肤并允许药物在体内递送来克服这种限制。尽管MP已经研究了几年，直到2017年左右,才报道了它们作为抗生药治疗的潜力.本文旨在总结和分析用于生产MP的策略，并嵌入抗肥胖的活性分子。特别关注的是微针的材料，几何图形,数组,和额外的交付策略，比如纳米封装。MP是开发易于访问的治疗方法的有希望的工具，避免消化道，并具有通过递送一种或多种活性分子来增强抗生生活性的能力。
