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Abstract：
Objectives: The aim of this study was to evaluate the relationship between absolute lymphocyte count (ALC) and outcomes of infrainguinal bypass surgery for chronic limb-threatening ischemia (CLTI). Methods: From 2004 to 2020, 209 limbs of 189 patients who underwent infrainguinal bypass surgery for CLTI and whose ALCs were available were included. Patients with survival >2 years and limb salvage >2 years were considered discriminant groups, and an ALC cut-off value was calculated. The relationship between preoperative ALC and outcomes was evaluated. Results: Survivorship of the higher ALC group was significantly higher than that of the lower ALC group (cut-off value 1030/μL, p = 0.0009). The limb salvage rate of the higher ALC group was significantly higher than that of the lower ALC group (cut-off value 1260/μL, p = 0.0081). In the dialysis patient group (103 limbs), the limb salvage rate of the higher ALC group was significantly higher than that of the lower ALC group (cut-off value 1170/μL, p = 0.026). ALC was independently associated with limb loss in multivariate analysis. Conclusion: ALC is promising as a predictor of outcomes after bypass surgery in CLTI. In particular, ALC is expected to be useful for limb prognosis in hemodialysis patients.
摘要：
目的：本研究的目的是评估绝对淋巴细胞计数（ALC）与慢性威胁肢体缺血（CLTI）的腹股沟下旁路手术结果之间的关系。方法：从2004年到2020年，包括189例接受CLTI的腹股沟下搭桥手术并具有ALCs的患者的209条肢体。生存>2年和保肢>2年的患者被认为是判别组，并计算ALC截止值。评估术前ALC与预后的关系。结果：高ALC组的存活率明显高于低ALC组（临界值1030/μL，p=0.0009)。高ALC组的保肢率明显高于低ALC组(临界值1260/μL,p=0.0081）。在透析患者组（103条肢体）中，高ALC组的保肢率明显高于低ALC组（临界值1170/μL，p=0.026)。在多变量分析中，ALC与肢体丢失独立相关。结论：ALC有望作为CLTI搭桥手术后预后的预测指标。特别是,ALC有望对血液透析患者的肢体预后有用。
