PDF(Pubmed)
Abstract：
Pleomorphic carcinoma (PC) is an uncommon and high-grade form of breast carcinoma characterized by the presence of distinctive pleomorphic giant tumor cells exhibiting bizarre nuclei and atypical mitosis. In this study, we report three patients who presented with lesions composed of a proliferation of large pleomorphic cells with a predominance of multinucleated giant cells on a microscope. Immunohistochemical analysis revealed distinct immunologic profiles within the respective malignant components. Notably, this report aims to contribute valuable insights, adding to the understanding of this uncommon tumor, accompanied by a literature review. Despite its rarity, PC in the breast remains clinically relevant due to its distinctive morphological and pathological features. These unique attributes require specific considerations in both clinical presentation and management.
摘要：
多形性癌（PC）是一种罕见的高级乳腺癌形式，其特征是存在独特的多形性巨大肿瘤细胞，表现出奇异的核和非典型的有丝分裂。在这项研究中,我们报告了3例患者，他们在显微镜下出现了由大型多形性细胞增生组成的病变，其中多核巨细胞占优势。免疫组织化学分析显示，在各个恶性成分中具有不同的免疫学特征。值得注意的是,这份报告旨在提供有价值的见解，增加了对这种罕见肿瘤的理解，伴随着文献综述。尽管它很罕见,由于其独特的形态学和病理学特征，乳腺中的PC仍然具有临床相关性。这些独特的属性需要在临床表现和管理方面进行具体考虑。
