PDF(Pubmed)
Abstract：
Heparin-induced thrombocytopenia is a rare and potentially devastating complication of heparin therapy. Patients with an absolute indication for anticoagulation, such as those with significant pulmonary embolism, must be switched to a different anticoagulant, such as argatroban, a direct thrombin inhibitor. We report a case of anaphylaxis to argatroban in a patient who was initially on heparin for intermediate-high risk pulmonary embolism but developed suspected type II heparin-induced thrombocytopenia. This case highlights the significance of recognizing and treating anaphylactic reactions and the diagnostic challenges associated with heparin-induced thrombocytopenia.
摘要：
肝素诱导的血小板减少症是肝素治疗的一种罕见且潜在的破坏性并发症。有绝对抗凝指征的患者，比如那些有严重肺栓塞的人，必须切换到不同的抗凝剂，比如阿加曲班，一种直接的凝血酶抑制剂.我们报告了一例对阿加曲班过敏的患者，该患者最初因中高危肺栓塞而服用肝素，但疑似II型肝素引起的血小板减少症。该病例强调了识别和治疗过敏性反应的重要性以及与肝素诱导的血小板减少症相关的诊断挑战。
