PDF(Pubmed)
Abstract：
Transcatheter aortic-valve replacement (TAVR) has evolved from a treatment strategy for high-risk patients to an option for low-risk individuals, prompting the need for rigorous comparisons with surgical aortic-valve replacement (SAVR). The German-Austrian Prospective Randomized Trial of Transcatheter Aortic Valve Implantation Versus Conventional Surgical Aortic Valve Replacement in Low and Intermediate Risk Patients (DEDICATE) trial compares low- and intermediate-risk patient undergoing SAVR and TAVR. This review outlines the trial design, key findings, strengths, and weaknesses of the study and also highlights the urgent need for standardized definitions of low-risk patients in future trials to ensure accurate comparisons and robust conclusions.
摘要：
经导管主动脉瓣置换术（TAVR）已从针对高风险患者的治疗策略发展为针对低风险个体的选择，提示需要与外科主动脉瓣置换术（SAVR）进行严格比较。在低和中等风险患者中，经导管主动脉瓣植入与常规外科主动脉瓣置换术的德国-奥地利前瞻性随机试验（DEDICATE）试验比较了接受SAVR和TAVR的低和中等风险患者。这篇综述概述了试验设计，关键发现,优势,和研究的弱点，并强调了在未来的试验中迫切需要低危患者的标准化定义，以确保准确的比较和可靠的结论。
