Abstract：
UNASSIGNED: Background. Food allergy can range from mild to severe, life-threatening reactions with various symptoms and organ involvement. The impact of asthma on severe food-induced allergic reactions is not completely understood. In the hypothesis that asthma increases the risk of severe food-induced allergic reactions, the aim of this study is to compare the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma. Methods. We performed a systematic research on electronic databases, including PubMed, Scopus, and Web of Science. Observational studies, studies reporting medical characteristics of patients diagnosed with food allergy, and studies reporting medical history of patients with allergic reactions were included. The primary outcome was the incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma. The protocol of this review was registered in PROSPERO (CRD42023448293). Results. Eight studies with a total of 90,367 patients met the inclusion criteria and were included, with a total population of 28,166 of patients with food allergy. The incidence of severe food-induced allergic reactions in patients with history of asthma compared with patients without history of asthma was increased (OR = 1.28; 95% CI 1.03-1.59; p = 0.03; I2 = 59%). Conclusions. Individuals with both food allergy and asthma are at high risk of severe, potentially fatal allergic reactions. Healthcare professionals should prioritize prevention and management strategies for these subjects.
摘要：
■背景。食物过敏可以从轻度到重度，具有各种症状和器官受累的危及生命的反应。哮喘对严重食物引起的过敏反应的影响尚不完全清楚。假设哮喘会增加严重食物引起的过敏反应的风险，本研究的目的是比较有哮喘病史的患者与无哮喘病史的患者中严重食物引起的过敏反应的发生率.方法。我们对电子数据库进行了系统的研究，包括PubMed,Scopus,和WebofScience。观察性研究,报告被诊断为食物过敏患者的医学特征的研究，并纳入报告有过敏反应患者病史的研究.主要结果是有哮喘病史的患者与没有哮喘病史的患者相比，严重的食物引起的过敏反应的发生率。本综述的方案在PROSPERO（CRD42023448293）中注册。结果。8项研究共90,367例患者符合纳入标准并被纳入,共有28,166名食物过敏患者。与无哮喘病史的患者相比，有哮喘病史的患者中严重食物引起的过敏反应的发生率增加（OR=1.28；95％CI1.03-1.59；p=0.03；I2=59％）。Conclusions.同时患有食物过敏和哮喘的人患严重的风险很高，可能致命的过敏反应.医疗保健专业人员应优先考虑这些主题的预防和管理策略。
