Abstract：
Association behavior between quinizarin (1,4-dihydroxyanthraquinone), an analogue of the chromophore of anthracycline anticancer drugs and sodium dodecyl sulfate (SDS) micelles in the presence of glucose, NaCl and urea additives was studied using absorption spectroscopy and conductometric techniques. The spectral results indicate an increase of binding constant and partition coefficient values in the presence of glucose and NaCl whereas the addition of urea leads to a decrease of binding strength and quinizarin partitioning into SDS micelles. Thus, the rise of NaCl and glucose concentrations is favorable for the quinizarin distribution into SDS micelles. From electrical conductivity measurements it was found that the critical micelle concentration (CMC) of SDS/quinizarin system decreases by adding NaCl and glucose whereas urea has not influence on the micelization process at the concentrations used in the present study. Since biologically compounds like glucose, NaCl and urea are found in the human body, the attained outcomes can be important in finding of effective drug delivery systems.
摘要：
奎尼扎素（1,4-二羟基蒽醌）的缔合行为，蒽环类抗癌药物发色团的类似物和十二烷基硫酸钠（SDS）胶束在葡萄糖的存在下，使用吸收光谱和电导技术研究了NaCl和尿素添加剂。光谱结果表明，在存在葡萄糖和NaCl的情况下，结合常数和分配系数值增加，而尿素的添加导致结合强度降低和奎尼扎素分配到SDS胶束中。因此，NaCl和葡萄糖浓度的升高有利于奎尼扎素在SDS胶束中的分布。从电导率测量中发现，通过添加NaCl和葡萄糖，SDS/quinizarin系统的临界胶束浓度（CMC）降低，而尿素在本研究中使用的浓度下对胶束化过程没有影响。因为像葡萄糖这样的生物化合物，NaCl和尿素存在于人体内,获得的结果对于发现有效的药物递送系统可能很重要。
