Abstract：
Traumatic and inherited cataract spiking blindness is caused by accumulated deposition of mutant eye lens protein or lens microarchitecture alteration. A traumatic cataract is a clouding of the eye\'s natural lens that occurs as a result of physical trauma to the eye. This trauma can be caused by various incidents such as blunt force injury, penetration by a foreign object, or a significant impact on the eye area. Inheritance cataracts or hereditary cataracts are cataracts that are genetically inherited from one or both parents. Complications following cataract surgery encompass various adverse outcomes such as inflammation, infection, bleeding, swelling, drooping eyelid, glaucoma, secondary cataracts, and complete loss of vision. The main purpose of the review is to highlight common pathophysiology associated with traumatic and inherited cataracts. Also, the review discusses diagnosis and treatment strategies for such cataract types by targeting their key pathological hallmarks. γD-crystallin plays a crucial role in maintaining the optical properties of the lens during the life span of an individual. Carbamazepine, Resveratrol, and Myricetin (CRM) are effectively bound at the γD-crystallin binding site and thereby could minimize misfolding and aggregation of γD-crystallin. miR-202, miR-193b, miR-135a, miR365, and miR-376a had the highest levels of abundance in the aqueous humor of individuals diagnosed with cataracts. The validation of these miRs will provide more insights into their functional roles and may be used for diagnostic purposes. The effective CRM combination as a multidrug formulation may postpone both traumatic and inherited cataracts and protect the eye from blindness.
摘要：
外伤性和遗传性白内障尖峰性失明是由突变眼晶状体蛋白的累积沉积或晶状体微结构改变引起的。外伤性白内障是由于眼睛的物理创伤而发生的眼睛自然晶状体的混浊。这种创伤可能是由钝器伤等各种事件引起的，被异物穿透，或对眼睛区域产生重大影响。遗传性白内障或遗传性白内障是遗传自父母一方或双方的白内障。白内障手术后的并发症包括各种不良后果，如炎症，感染,出血,肿胀,下垂的眼睑，青光眼,继发性白内障,完全丧失视力.这篇综述的主要目的是强调与创伤性和遗传性白内障相关的常见病理生理学。此外，该综述通过针对此类白内障的关键病理特征讨论了其诊断和治疗策略。γD-晶状体蛋白在维持个体寿命期间透镜的光学性质中起着至关重要的作用。卡马西平,白藜芦醇,和杨梅素（CRM）有效地结合在γD-晶状体蛋白结合位点，从而可以最大程度地减少γD-晶状体蛋白的错误折叠和聚集。miR-202,miR-193b,miR-135a,miR365和miR-376a在被诊断患有白内障的个体的房水中具有最高水平的丰度。这些miR的验证将提供对其功能作用的更多见解，并可用于诊断目的。有效的CRM组合作为多药物制剂可以推迟创伤性和遗传性白内障，并保护眼睛免受失明。
