Abstract：
Multidrug-resistant Staphylococcus aureus is a serious public health problem with high fatality rates and difficult treatment. Conventional antimicrobials are limited in their effectiveness against MRSA due to developing resistance mechanisms and protective biofilms. Nanomaterials present a potential alternative since they offer targeted drug delivery and synergetic effects of nanoconjugates, eradicate biofilms, and use photothermal and photodynamic therapies. Furthermore, the discovery of nanovaccines holds the potential for enhancing immune responses against multidrugresistant S. aureus. Nanoparticles show considerable promise in the battle against multidrugresistant S. aureus, but significant obstacles remain, including determining their possible toxicity, scalability, and cost-effectiveness for widespread clinical application. However, by overcoming these barriers, nanomaterial-based techniques provide a viable route for tackling multidrug resistance in S. aureus, opening the path for a future in which successful therapies are within reach.
摘要：
多重耐药金黄色葡萄球菌是严重的公共卫生问题，病死率高，治疗困难。由于产生抗性机制和保护性生物膜,常规抗微生物剂对MRSA的有效性受到限制。纳米材料提供了一个潜在的替代品，因为它们提供了靶向药物递送和纳米缀合物的协同作用，根除生物膜，并使用光热和光动力疗法。此外，纳米疫苗的发现具有增强针对多重耐药金黄色葡萄球菌的免疫应答的潜力。纳米颗粒在对抗多重耐药金黄色葡萄球菌的战斗中显示出相当大的希望，但是仍然存在重大障碍，包括确定它们可能的毒性，可扩展性，和广泛临床应用的成本效益。然而,通过克服这些障碍，基于纳米材料的技术为解决金黄色葡萄球菌的多药耐药性提供了可行的途径，为未来开辟了道路，在未来中，成功的治疗是可以实现的。
