Abstract：
BACKGROUND: Melasma, a chronic acquired skin pigmentation disorder, is characterized by the presence of irregular-edged brown to gray-brown patches with a symmetrical distribution, primarily on sun-exposed areas such as the face. Topical hydroquinone (HQ) is the gold standard for melasma treatment but has numerous side effects. This study assesses the effectiveness of topical tranexamic acid (TA) as an alternative for melasma treatment.
METHODS: In a double-blind, split-face, randomized controlled trial involving 20 subjects, the effectiveness of 3% TA versus 4% HQ cream was evaluated over 8 weeks. The modified melasma area and severity index (mMASI), melanin index, erythema index, and side effects were assessed. Subjective improvement was measured using the patient global assessment (PtGA).
RESULTS: A significant decline in the mMASI score was observed at weeks 4 and 8 in both groups compared to baseline. There were no statistically significant differences in PtGA scores between the 3% TA group and the 4% HQ group.
CONCLUSIONS: Topical 3% TA is as effective and safe as 4% HQ for treating melasma in the Indonesian population, with potential advantages in terms of side-effect profiles.
METHODS: In a double-blind, split-face, randomized controlled trial involving 20 subjects, the effectiveness of 3% TA versus 4% HQ cream was evaluated over 8 weeks. The modified melasma area and severity index (mMASI), melanin index, erythema index, and side effects were assessed. Subjective improvement was measured using the patient global assessment (PtGA).
RESULTS: A significant decline in the mMASI score was observed at weeks 4 and 8 in both groups compared to baseline. There were no statistically significant differences in PtGA scores between the 3% TA group and the 4% HQ group.
CONCLUSIONS: Topical 3% TA is as effective and safe as 4% HQ for treating melasma in the Indonesian population, with potential advantages in terms of side-effect profiles.
摘要：
背景：黄褐斑，慢性获得性皮肤色素沉着症,其特征是存在不规则边缘的棕色到灰棕色斑块，具有对称分布，主要是在阳光照射的地方，如面部。局部氢醌（HQ）是治疗黑斑病的金标准，但有许多副作用。这项研究评估了局部氨甲环酸（TA）作为黑斑病治疗替代品的有效性。
方法：在双盲中，分割面,涉及20名受试者的随机对照试验，在8周内评估了3％TA与4％HQ乳膏的有效性。修改后的黄褐斑面积和严重程度指数（mMASI），黑色素指数,红斑指数,和副作用进行了评估。使用患者整体评估(PtGA)测量主观改善。
结果：与基线相比，两组在第4周和第8周观察到mMASI评分显着下降。3%TA组和4%HQ组的PtGA评分无统计学差别。
结论：外用3％TA与4％HQ一样有效且安全，可治疗印度尼西亚人群中的黄褐斑，在副作用方面具有潜在的优势。
方法：在双盲中，分割面,涉及20名受试者的随机对照试验，在8周内评估了3％TA与4％HQ乳膏的有效性。修改后的黄褐斑面积和严重程度指数（mMASI），黑色素指数,红斑指数,和副作用进行了评估。使用患者整体评估(PtGA)测量主观改善。
结果：与基线相比，两组在第4周和第8周观察到mMASI评分显着下降。3%TA组和4%HQ组的PtGA评分无统计学差别。
结论：外用3％TA与4％HQ一样有效且安全，可治疗印度尼西亚人群中的黄褐斑，在副作用方面具有潜在的优势。
