Abstract:
In rodents and primates, interval estimation has been associated with a complex network of cortical and subcortical structures where the dorsal striatum plays a paramount role. Diverse evidence ranging from individual neurons to population activity has demonstrated that this area hosts temporal-related neural representations that may be instrumental for the perception and production of time intervals. However, little is known about how temporal representations interact with other well-known striatal representations, such as kinematic parameters of movements or somatosensory representations. An attractive hypothesis suggests that somatosensory representations may serve as the scaffold for complex representations such as elapsed time. Alternatively, these representations may coexist as independent streams of information that could be integrated into downstream nuclei, such as the substantia nigra or the globus pallidus. In this review, we will revise the available information suggesting an instrumental role of sensory representations in the construction of temporal representations at population and single-neuron levels throughout the basal ganglia.
摘要:
在啮齿动物和灵长类动物中,间隔估计与皮质和皮质下结构的复杂网络有关,其中背侧纹状体起着至关重要的作用。从单个神经元到种群活动的各种证据表明,该区域具有与时间相关的神经表征,可能有助于感知和产生时间间隔。然而,关于时间表征如何与其他众所周知的纹状体表征相互作用知之甚少,例如运动的运动学参数或体感表征。一个有吸引力的假设表明,体感表征可以作为复杂表征的支架,例如经过的时间。或者,这些表示可以作为独立的信息流共存,可以整合到下游原子核中,如黑质或苍白球。在这次审查中,我们将修订现有的信息,这些信息表明感觉表征在整个基底神经节的人群和单神经元水平上的时间表征的构建中起着重要作用。