Abstract：
OBJECTIVE: The management of primary hyperparathyroidism (PHPT) during pregnancy may be surgical or conservative. This study compared adverse outcomes between surgical and non-surgical treatments. Additionally, the study investigated the correlation between serum calcium values and complication rates.
METHODS: A systematic review of retrospective studies, case series, and case reports. Biochemical parameters, interventions, and outcomes of each pregnancy were recorded. The study population comprised two groups: the non-surgical and surgical groups. Adverse outcomes were categorized as maternal, obstetric, or neonatal.
RESULTS: The surgical and non-surgical groups consisted of 163 and 185 patients, respectively. A positive correlation was observed between the mean maternal gestational calcium value and both maternal and obstetric complication. Neonatal complications were more prevalent in patients treated conservatively across all maternal calcium values (p < 0.001). No significant differences were observed in maternal outcomes and overall obstetric outcomes between the study groups, albeit a higher mean serum calcium value in the surgical group (12.3 mg/dL) compared with the non-surgical group (11.1 mg/dL).
CONCLUSIONS: Given the significantly lower neonatal adverse outcomes in the non-surgical group compared to the surgical group, along with non-inferior maternal and obstetric outcomes in the surgical group, the overall data of this study suggest that parathyroidectomy is favorable to non-surgical management even in cases of mild hypercalcemia.
METHODS: A systematic review of retrospective studies, case series, and case reports. Biochemical parameters, interventions, and outcomes of each pregnancy were recorded. The study population comprised two groups: the non-surgical and surgical groups. Adverse outcomes were categorized as maternal, obstetric, or neonatal.
RESULTS: The surgical and non-surgical groups consisted of 163 and 185 patients, respectively. A positive correlation was observed between the mean maternal gestational calcium value and both maternal and obstetric complication. Neonatal complications were more prevalent in patients treated conservatively across all maternal calcium values (p < 0.001). No significant differences were observed in maternal outcomes and overall obstetric outcomes between the study groups, albeit a higher mean serum calcium value in the surgical group (12.3 mg/dL) compared with the non-surgical group (11.1 mg/dL).
CONCLUSIONS: Given the significantly lower neonatal adverse outcomes in the non-surgical group compared to the surgical group, along with non-inferior maternal and obstetric outcomes in the surgical group, the overall data of this study suggest that parathyroidectomy is favorable to non-surgical management even in cases of mild hypercalcemia.
摘要：
目的：妊娠期原发性甲状旁腺功能亢进（PHPT）的治疗可以是手术治疗，也可以是保守治疗。这项研究比较了手术和非手术治疗的不良结果。此外,这项研究调查了血清钙值与并发症发生率之间的相关性。
方法：回顾性研究的系统综述，案例系列,和病例报告。生化参数,干预措施，并记录每次妊娠的结局.研究人群包括两组：非手术组和手术组。不良结局被归类为孕产妇，产科,或新生儿。
结果：手术组和非手术组分别为163和185例患者，分别。孕妇平均孕钙值与母婴并发症呈正相关。在所有母体钙值中保守治疗的患者中，新生儿并发症更为普遍（p<0.001）。研究组之间的产妇结局和总体产科结局没有显着差异，尽管手术组的平均血清钙值（12.3mg/dL）高于非手术组（11.1mg/dL）。
结论：鉴于非手术组新生儿不良结局明显低于手术组，除了手术组的非劣质孕产妇和产科结果，本研究的总体数据表明,即使在轻度高钙血症的情况下,甲状旁腺切除术也有利于非手术治疗.
方法：回顾性研究的系统综述，案例系列,和病例报告。生化参数,干预措施，并记录每次妊娠的结局.研究人群包括两组：非手术组和手术组。不良结局被归类为孕产妇，产科,或新生儿。
结果：手术组和非手术组分别为163和185例患者，分别。孕妇平均孕钙值与母婴并发症呈正相关。在所有母体钙值中保守治疗的患者中，新生儿并发症更为普遍（p<0.001）。研究组之间的产妇结局和总体产科结局没有显着差异，尽管手术组的平均血清钙值（12.3mg/dL）高于非手术组（11.1mg/dL）。
结论：鉴于非手术组新生儿不良结局明显低于手术组，除了手术组的非劣质孕产妇和产科结果，本研究的总体数据表明,即使在轻度高钙血症的情况下,甲状旁腺切除术也有利于非手术治疗.
