Abstract：
OBJECTIVE: To explore the experiences of utilising distal-extremity cryotherapy in reducing chemotherapy-induced peripheral neuropathy during Paclitaxel treatment on physical functioning, clinical and patient-reported outcomes, compared to standard care in people affected by breast cancer.
METHODS: Four databases and one register were searched on 11 April 2023 to identify all relevant studies meeting the inclusion and exclusion criteria. These were CINAHL (via EBSCOhost), Cochrane Central Register of Controlled Trials, Medline (via EBSCOhost), Scopus, and Web of Science Core Collection, with no limiters placed on any of the searches. Additionally, relevant systematic reviews were scrutinised for potentially relevant studies for screening.
RESULTS: Distal-extremity cryotherapy is a safe intervention with minimal risk for serious adverse events. However, insufficient data supports the mainstay clinical use of cryotherapy in reducing chemotherapy-induced peripheral neuropathy from Paclitaxel use within the breast cancer population. Heterogeneity in study design, cryotherapy mode, and measurement tools underscore the need for additional research.
CONCLUSIONS: Despite limited data on the impact of distal-extremity cryotherapy in preventing chemotherapy-induced peripheral neuropathy, there are valuable implications for nursing practice arising from this review.
CONCLUSIONS: Nurses play a vital role in the clinical and experiential journey of people with breast cancer, it is important that they understand the available evidence and act as patient advocates. Assisting patients in understanding current research and encouraging participation in future studies, thereby enhancing our knowledge, and strengthening the available evidence base.
METHODS: Four databases and one register were searched on 11 April 2023 to identify all relevant studies meeting the inclusion and exclusion criteria. These were CINAHL (via EBSCOhost), Cochrane Central Register of Controlled Trials, Medline (via EBSCOhost), Scopus, and Web of Science Core Collection, with no limiters placed on any of the searches. Additionally, relevant systematic reviews were scrutinised for potentially relevant studies for screening.
RESULTS: Distal-extremity cryotherapy is a safe intervention with minimal risk for serious adverse events. However, insufficient data supports the mainstay clinical use of cryotherapy in reducing chemotherapy-induced peripheral neuropathy from Paclitaxel use within the breast cancer population. Heterogeneity in study design, cryotherapy mode, and measurement tools underscore the need for additional research.
CONCLUSIONS: Despite limited data on the impact of distal-extremity cryotherapy in preventing chemotherapy-induced peripheral neuropathy, there are valuable implications for nursing practice arising from this review.
CONCLUSIONS: Nurses play a vital role in the clinical and experiential journey of people with breast cancer, it is important that they understand the available evidence and act as patient advocates. Assisting patients in understanding current research and encouraging participation in future studies, thereby enhancing our knowledge, and strengthening the available evidence base.
摘要：
目的：探讨应用远端肢体冷冻疗法减少紫杉醇治疗期间化疗引起的周围神经病变对机体功能的影响。临床和患者报告的结果，与受乳腺癌影响的人的标准护理相比。
方法：于2023年4月11日检索了四个数据库和一个登记册，以确定所有符合纳入和排除标准的相关研究。这些是CINAHL(通过EBSCOhost)，Cochrane中央控制试验登记册,Medline（通过EBSCOhost），Scopus,和WebofScience核心合集,对任何搜索都没有限制。此外,我们对相关的系统评价进行了仔细审查,以寻找潜在的相关筛查研究.
结果：远端肢体冷冻治疗是一种安全的干预措施，发生严重不良事件的风险最小。然而,在乳腺癌人群中,没有足够的数据支持冷冻疗法在减少因使用紫杉醇引起的化疗引起的周围神经病变方面的主要临床应用.研究设计中的异质性，冷冻治疗模式,和测量工具强调了额外研究的必要性。
结论：尽管关于远端肢体冷冻疗法预防化疗引起的周围神经病变的影响的数据有限，这篇综述对护理实践有价值的启示。
结论：护士在乳腺癌患者的临床和经验旅程中起着至关重要的作用，重要的是，他们了解现有的证据，并作为病人的倡导者。协助患者了解当前研究并鼓励参与未来研究，从而提高我们的知识，加强现有证据基础。
方法：于2023年4月11日检索了四个数据库和一个登记册，以确定所有符合纳入和排除标准的相关研究。这些是CINAHL(通过EBSCOhost)，Cochrane中央控制试验登记册,Medline（通过EBSCOhost），Scopus,和WebofScience核心合集,对任何搜索都没有限制。此外,我们对相关的系统评价进行了仔细审查,以寻找潜在的相关筛查研究.
结果：远端肢体冷冻治疗是一种安全的干预措施，发生严重不良事件的风险最小。然而,在乳腺癌人群中,没有足够的数据支持冷冻疗法在减少因使用紫杉醇引起的化疗引起的周围神经病变方面的主要临床应用.研究设计中的异质性，冷冻治疗模式,和测量工具强调了额外研究的必要性。
结论：尽管关于远端肢体冷冻疗法预防化疗引起的周围神经病变的影响的数据有限，这篇综述对护理实践有价值的启示。
结论：护士在乳腺癌患者的临床和经验旅程中起着至关重要的作用，重要的是，他们了解现有的证据，并作为病人的倡导者。协助患者了解当前研究并鼓励参与未来研究，从而提高我们的知识，加强现有证据基础。
