Abstract：
Linc00265, a long intergenic non-coding RNA, has garnered significant research attention due to its involvement in various human diseases, particularly cancer. It exhibits tissue-specific and dysregulated expression across multiple cancer types, including blood malignancies, colorectal, gastric, bladder, osteosarcoma, and hepatocellular carcinoma. This dysregulation is often associated with tumor aggressiveness, metastasis, and poor prognosis. Moreover, aberrant expression of Linc00265 has been reported in inflammation-related diseases such as osteoarthritis and sepsis. Mechanistically, Linc00265 acts as a competing endogenous RNA (CeRNA), sequestering specific microRNAs and thereby modulating their downstream targets. Additionally, it influences critical signaling pathways by mediating the key effectors within these pathways. Importantly, the dysregulation of Linc00265 shows promising potential as a diagnostic and prognostic biomarker in several human diseases. This review aims to comprehensively analyze the expression patterns, regulatory mechanisms, and potential biomarker roles of Linc00265 in human diseases, with a particular focus on cancer. By elucidating the functional implications of Linc00265, we can deepen our understanding of its roles in human diseases, potentially paving the way for novel therapeutic interventions in disease management.
摘要：
Linc00265，一种长的基因间非编码RNA，由于其参与各种人类疾病而获得了重要的研究关注，尤其是癌症。它在多种癌症类型中表现出组织特异性和失调的表达，包括血液恶性肿瘤,结直肠,胃,膀胱,骨肉瘤,和肝细胞癌。这种失调通常与肿瘤侵袭性有关，转移,预后不良。此外，据报道，Linc00265在炎症相关疾病如骨关节炎和败血症中的异常表达。机械上,Linc00265充当竞争内源性RNA（CeRNA），螯合特定的microRNA，从而调节其下游靶标。此外,它通过介导这些途径中的关键效应子影响关键信号通路。重要的是,Linc00265的失调在几种人类疾病中显示出作为诊断和预后生物标志物的潜力.这篇综述旨在全面分析表达模式，监管机制,以及Linc00265在人类疾病中的潜在生物标志物作用，特别关注癌症。通过阐明Linc00265的功能含义，我们可以加深对其在人类疾病中的作用的理解，可能为疾病管理中的新型治疗干预措施铺平道路。
