Abstract：
This systematic review aimed at investigating the role that biosecurity can have in preventing or controlling colibacillosis in broiler production. Primary studies with natural or experimental exposure to avian pathogenic Escherichia coli, evaluating any biosecurity measure to prevent or control colibacillosis in broiler chickens with at least one of the following outcomes: feed conversion ratio (FCR), condemnations at slaughter, and mortality due to colibacillosis, were included. A systematic search was carried out in 4 databases according to the Cochrane handbook and reported following the PRISMA 2020 directions. Studies (n = 3,886) were screened in a 2-phase process and data matching the inclusion criteria were extracted. Risk of bias assessment was performed. Four studies reporting biosecurity measures to prevent or control colibacillosis in broiler production were included. In all studies, only disinfection during either the pre-hatching period (n = 3) or the post-hatching period (n = 1) was evaluated as biosecurity measure in broiler production, as well as its effect on FCR (n = 2) and mortality (n = 4) due to colibacillosis. No studies with effects on condemnations at slaughter were found. Due to the heterogeneity of studies in regard to interventions and outcomes, meta-analysis was not carried out. The limited findings of this systematic review do not provide a comprehensive evidence to statistically evaluate the efficacy of biosecurity to prevent or control colibacillosis in broiler production. The scarcity of evidence found suggests that further and deeper investigations on the topic are needed, considering the variety of interventions related to biosecurity.
摘要：
本系统综述旨在研究生物安全性在预防或控制肉鸡生产中大肠杆菌病方面的作用。与自然或实验暴露于禽类致病性大肠杆菌的初步研究，评估任何生物安全措施以预防或控制肉鸡大肠杆菌病，至少具有以下结果之一：饲料转化率（FCR），谴责屠杀，和大肠杆菌病导致的死亡率，包括在内。根据Cochrane手册，在4个数据库中进行了系统搜索，并按照PRISMA2020方向进行了报告。在2阶段筛选研究（n=3,886），并提取符合纳入标准的数据。进行偏倚风险评估。包括四项报告预防或控制肉鸡生产中大肠杆菌病的生物安全措施的研究。在所有研究中,仅在孵化前（n=3）或孵化后（n=1）期间的消毒被评估为肉鸡生产中的生物安全措施，以及它对大肠杆菌病引起的FCR（n=2）和死亡率（n=4）的影响。没有发现对屠杀谴责有影响的研究。由于干预措施和结果研究的异质性，没有进行荟萃分析。本系统评价的有限发现没有提供全面的证据来统计评估生物安全性预防或控制肉鸡生产中大肠杆菌病的有效性。缺乏证据表明，需要对该主题进行进一步深入的调查，考虑到与生物安全相关的各种干预措施。
