PDF(Pubmed)
Abstract：
The transformation of salvianolic acid B brought on by heat treatment recovery of ethanol eluent, which is a difficult problem in pharmaceutical technology, affects the purity of raw material when the medicinal raw material salvianolic acid B is purified by resin. Ultrasonic-assisted nanofiltration separation (UANS) was first employed to improve efficiency of resource utilization by regulating rejection and separating salvianolic acid B and rosmarinic acid from organic pharmaceutical wastewater. The rejection was related to three variables: ultrasonic power, pH, and ethanol concentration. But there were differences in the effects of variables on the rejections of salvianolic acid B and rosmarinic acid. The rejections of rosmarinic acid and salvianolic acid B showed a decreasing trend with an increase in ultrasonic power or a decrease in pH; however, when the concentration of ethanol was increased from 5 % to 35 %, the salvianolic acid B rejection increased from 84.96 % to 96.60 % and the rosmarinic acid rejection decreased from 35.09 % to 17.51 %. On the basis of response surface methodology (RSM), the optimal UANS parameters for solution conditions involving different ethanol concentrations are as follows: 10 % ethanol solution (ultrasonic power 500 W and pH 6.15), 20 % ethanol solution (ultrasonic power 500 W and pH 6.54), and 30 % ethanol solution (ultrasonic power 460 W and pH 6.34). The molecular proportions of salvianolic acid B were 10.75 %, 7.13 %, and 8.27 % in 10 %, 20 %, and 30 % ethanol wastewater, while the molecular proportions of rosmarinic acid were 40.52 %, 33.83 %, and 69.87 %, respectively. And the recoveries of salvianolic acid B in 10 %, 20 %, and 30 % ethanol wastewater were 93.56 %, 95.04 %, and 97.30 %, respectively, while the recoveries of rosmarinic acid were 3.19 %, 2.27 %, and 0.56 %. The molecular proportion and the rejection are correlated exponentially. In comparison with conventional nanofiltration separation (CNS), UANS is able to resolve the conflict between rosmarinic acid and salvianolic acid B in pharmaceutical wastewater, as well as enhance resource recycling and separation efficiency to prevent pollution of the environment from pharmaceutical wastewater. Experiments using UANS at different power intensities suggest that the ultrasonic at a power intensity of 46-50 W/L and the power density of 0.92-1.00 W/cm2 may resolve the separation conflict between rosmarinic acid and salvianolic acid B. This work suggests that UANS may be a significant advancement in the field of ultrasonic separation and has several potential uses in the water treatment industry.
摘要：
乙醇洗脱液热处理回收对丹酚酸B的转化,这是制药技术中的一个难题，药用原料丹酚酸B经树脂纯化后,会影响原料的纯度。超声波辅助纳滤分离(UANS)首先通过调节截留率和从有机制药废水中分离丹酚酸B和迷迭香酸来提高资源利用率。排斥与三个变量有关：超声功率，pH值,和乙醇浓度。但变量对丹酚酸B和迷迭香酸的排斥反应的影响存在差异。迷迭香酸和丹酚酸B的截留率随着超声功率的增加或pH的降低而呈下降趋势;当乙醇的浓度从5%增加到35%时，丹酚酸B的排斥率从84.96％提高到96.60％，迷迭香酸的排斥率从35.09％降低到17.51％。在响应面法(RSM)的基础上，不同乙醇浓度溶液的最佳UANS参数如下:10%乙醇溶液(超声功率500W,pH6.15),20％乙醇溶液（超声功率500W，pH6.54），和30%乙醇溶液(超声功率460W和pH6.34)。丹酚酸B的分子比例为10.75%,7.13%,和8.27%的10%，20%,和30%的乙醇废水，迷迭香酸的分子比例为40.52%，33.83%,和69.87%，分别。丹酚酸B的回收率为10%,20%,30%乙醇废水为93.56%，95.04%,和97.30%，分别,而迷迭香酸的回收率为3.19%，2.27%,和0.56%。分子比例和截留率呈指数相关。与传统的纳滤分离（CNS）相比，UANS能够解决制药废水中迷迭香酸和丹酚酸B之间的冲突，以及提高资源回收和分离效率，防止制药废水污染环境。在不同功率强度下使用UANS的实验表明，功率强度为46-50W/L，功率密度为0.92-1.00W/cm2的超声可以解决迷迭香酸和丹酚酸B之间的分离冲突。这项工作表明，UANS可能是超声分离领域的重大进展，在水处理行业中具有多种潜在用途。
