Abstract：
The extent of changes in functional connectivity (FC) within functional networks as a common feature across hallucinogenic drug classes is under-explored. This work utilized fMRI to assess the dissociative hallucinogens Psilocybin, a classical serotonergic psychedelic, and Salvinorin-A, a kappa-opioid receptor (KOR) agonist, on resting-state FC in nonhuman primates. We highlight overlapping and differing influence of these substances on FC relative to the thalamus, claustrum, prefrontal cortex (PFC), default mode network (DMN), and DMN subcomponents. Analysis was conducted on a within-subject basis. Findings support the cortico-claustro-cortical network model for probing functional effects of hallucinogens regardless of serotonergic potential, with a potential key paradigm centered around the claustrum, PFC, anterior cingulate cortices (ACC), and angular gyrus relationship. Thalamo-cortical networks are implicated but appear dependent on 5-HT2AR activation. Acute desynchronization relative to the DMN for both drugs was also shown. Our findings provide a framework to understand broader mechanisms at which hallucinogens in differing classes may impact subjects regardless of the target receptor.
摘要：
作为致幻药物类别的共同特征，功能网络中功能连通性（FC）的变化程度尚未得到充分探索。这项工作利用功能磁共振成像来评估解离性致幻剂Psilocybin，经典的血清素迷幻药，和Salvinorin-A,κ阿片受体（KOR）激动剂，关于非人灵长类动物的静息状态FC。我们强调这些物质相对于丘脑对FC的重叠和不同影响，claustrum,前额叶皮质(PFC),默认模式网络(DMN)，和DMN子组件。分析是在受试者内部进行的。研究结果支持皮质-claustro-皮质网络模型，用于探测致幻剂的功能作用，无论血清素能潜能如何，一个潜在的关键范式围绕着claustrum，PFC,前扣带回皮质（ACC），和角回的关系.Thalamo-皮层网络有牵连，但似乎依赖于5-HT2AR激活。还显示了两种药物相对于DMN的急性去同步。我们的发现提供了一个框架，以了解更广泛的机制，无论目标受体如何，不同类别的致幻剂都可能影响受试者。
