Abstract：
UNASSIGNED: The aim of this study was to evaluate the prevalence, type and treatment outcomes of ocular involvement in patients with brucellosis.
UNASSIGNED: This prospective, single-center study enrolled patients admitted to the infectious disease outpatient clinic with diagnosed brucellosis between July 15, 2022 and July 15, 2023. Diagnosis was based on clinical symptoms and a standard Brucella tube agglutination test (≥1/160) or a positive blood culture. Ophthalmologic examinations were performed at baseline and in the first month of treatment. Third and sixth month follow-up examinations were also performed for patients with ocular findings.
UNASSIGNED: Ocular involvement occurred in 60 (24.8%) of 242 patients. Conjunctivitis was the most common ocular involvement and was observed in 39 patients (16.1%). Uveitis was the second most common ocular involvement in 14 patients (5.8%). Scleritis was the least common ocular involvement and was observed in only one patient. Patients with ocular involvement were older (p = 0.027) and had higher rates of weight loss and spondylodiscitis (p = 0.044 and 0.001, respectively). Among laboratory parameters, erythrocyte sedimentation rate and lactate dehydrogenase levels were significantly higher in patients with ocular involvement (p = 0.001 and 0.036, respectively). There were no significant differences in other demographic, clinical, and laboratory characteristics between patients with and without ocular involvement. In 56 (93.3%) patients, the ocular findings improved during the follow-up examination.
UNASSIGNED: Brucellosis, a systemic infection, can manifest with ocular involvement. Early detection and treatment through ophthalmological examination are crucial in managing brucellosis.
UNASSIGNED: This prospective, single-center study enrolled patients admitted to the infectious disease outpatient clinic with diagnosed brucellosis between July 15, 2022 and July 15, 2023. Diagnosis was based on clinical symptoms and a standard Brucella tube agglutination test (≥1/160) or a positive blood culture. Ophthalmologic examinations were performed at baseline and in the first month of treatment. Third and sixth month follow-up examinations were also performed for patients with ocular findings.
UNASSIGNED: Ocular involvement occurred in 60 (24.8%) of 242 patients. Conjunctivitis was the most common ocular involvement and was observed in 39 patients (16.1%). Uveitis was the second most common ocular involvement in 14 patients (5.8%). Scleritis was the least common ocular involvement and was observed in only one patient. Patients with ocular involvement were older (p = 0.027) and had higher rates of weight loss and spondylodiscitis (p = 0.044 and 0.001, respectively). Among laboratory parameters, erythrocyte sedimentation rate and lactate dehydrogenase levels were significantly higher in patients with ocular involvement (p = 0.001 and 0.036, respectively). There were no significant differences in other demographic, clinical, and laboratory characteristics between patients with and without ocular involvement. In 56 (93.3%) patients, the ocular findings improved during the follow-up examination.
UNASSIGNED: Brucellosis, a systemic infection, can manifest with ocular involvement. Early detection and treatment through ophthalmological examination are crucial in managing brucellosis.
摘要：
■这项研究的目的是评估患病率，布鲁氏菌病患者眼部受累的类型和治疗结果。
■这个前景，单中心研究纳入了2022年7月15日至2023年7月15日期间在传染病门诊就诊并确诊为布鲁氏菌病的患者.诊断基于临床症状和标准布鲁氏菌管凝集试验（≥1/160）或阳性血培养。在基线和治疗的第一个月进行眼科检查。还对有眼部表现的患者进行了第3个月和第6个月的随访检查。
■242例患者中有60例（24.8%）发生眼部受累。结膜炎是最常见的眼部受累，在39例患者中观察到（16.1%）。葡萄膜炎是14例患者中第二常见的眼部受累（5.8％）。巩膜炎是最不常见的眼部受累，仅在一名患者中观察到。眼部受累患者年龄较大（p=0.027），体重减轻和脊椎盘炎的发生率更高（分别为p=0.044和0.001）。在实验室参数中，眼部受累患者的红细胞沉降率和乳酸脱氢酶水平显着升高（分别为p=0.001和0.036）。在其他人口统计学上没有显着差异，临床,以及有和没有眼部受累的患者的实验室特征。在56名（93.3%）患者中，随访检查期间眼部发现改善.
■布鲁氏菌病，全身性感染,可以表现为眼部受累。通过眼科检查的早期发现和治疗对于控制布鲁氏菌病至关重要。
■这个前景，单中心研究纳入了2022年7月15日至2023年7月15日期间在传染病门诊就诊并确诊为布鲁氏菌病的患者.诊断基于临床症状和标准布鲁氏菌管凝集试验（≥1/160）或阳性血培养。在基线和治疗的第一个月进行眼科检查。还对有眼部表现的患者进行了第3个月和第6个月的随访检查。
■242例患者中有60例（24.8%）发生眼部受累。结膜炎是最常见的眼部受累，在39例患者中观察到（16.1%）。葡萄膜炎是14例患者中第二常见的眼部受累（5.8％）。巩膜炎是最不常见的眼部受累，仅在一名患者中观察到。眼部受累患者年龄较大（p=0.027），体重减轻和脊椎盘炎的发生率更高（分别为p=0.044和0.001）。在实验室参数中，眼部受累患者的红细胞沉降率和乳酸脱氢酶水平显着升高（分别为p=0.001和0.036）。在其他人口统计学上没有显着差异，临床,以及有和没有眼部受累的患者的实验室特征。在56名（93.3%）患者中，随访检查期间眼部发现改善.
■布鲁氏菌病，全身性感染,可以表现为眼部受累。通过眼科检查的早期发现和治疗对于控制布鲁氏菌病至关重要。
