Abstract：
Over the past decades, research has clearly established the important role of the mineralocorticoid receptor (MR) in both renal and extra-renal tissues. Recently, caveolin-1 (Cav-1) has emerged as a mediator of MR signaling in several tissues, with implications on cardiovascular and metabolic dysfunction. The main structural component of caveolae (plasma membrane invaginations with diverse functions), Cav-1 is a modulator of cardiovascular function, cellular glucose, and lipid homeostasis, via its effects on signal transduction pathways that mediate inflammatory responses and oxidative stress. In this review, we present evidence indicating an overlap between the roles of the MR and Cav-1 in cardiometabolic disease and the relevant signaling pathways involved. Furthermore, we discuss the potential use of Cav-1 as a biomarker and/or target for MR-mediated dysfunction.
摘要：
在过去的几十年里，研究已经清楚地确定了盐皮质激素受体（MR）在肾脏和肾外组织中的重要作用。最近,caveolin-1（Cav-1）已成为几种组织中MR信号传导的介质，对心血管（CV）和代谢功能障碍的影响。小窝的主要结构成分（具有不同功能的质膜内陷），Cav-1是心血管功能的调节剂,细胞葡萄糖和脂质稳态，通过其对介导炎症反应和氧化应激的信号转导途径的影响。在这次审查中,我们提供的证据表明MR和Cav-1在心脏代谢疾病中的作用与相关信号通路之间存在重叠.此外，我们讨论了Cav-1作为MR介导的功能障碍的生物标志物和/或靶标的潜在用途。
