Abstract：
Patients with central neuronal damage may suffer severe consequences, but effective therapies remain unclear. Previous research has established the transplantation of neural stem cells that generate new neurons to replace damaged ones. In a new field of scientific research, the extracellular secretion of NPSCs (NSPCs-ES) has been identified as an alternative to current chemical drugs. Many preclinical studies have shown that NSPCs-ES are effective in models of various central nervous system diseases (CNS) injuries, from maintaining functional structures at the cellular level to providing anti-inflammatory functions at the molecular level, as well as improving memory and motor functions, reducing apoptosis in neurons, and mediating multiple signaling pathways. The NSPC-ES can travel to the damaged tissue and exert a broad range of therapeutic effects by supporting and nourishing damaged neurons. However, gene editing and cell engineering techniques have recently improved therapeutic efficacy by modifying NSPCs-ES. Consequently, future research and application of NSPCs-ES may provide a novel strategy for the treatment of CNS diseases in the future. In this review, we summarize the current progress on these aspects.
摘要：
中枢神经损伤患者可能会遭受严重的后果，但有效的治疗方法仍不清楚。先前的研究已经建立了神经干细胞的移植，产生新的神经元来代替受损的神经元。在一个新的科学研究领域，NPSC（NSPCs-ES）的细胞外分泌已被确定为当前化学药物的替代品。许多临床前研究表明，NSPCs-ES在各种中枢神经系统疾病（CNS）损伤模型中有效，从维持细胞水平的功能结构到提供分子水平的抗炎功能，以及改善记忆和运动功能，减少神经元的凋亡，并介导多种信号通路。NSPC-ES可以传播到受损组织并通过支持和滋养受损神经元发挥广泛的治疗作用。然而,基因编辑和细胞工程技术最近通过修饰NSPCs-ES提高了治疗效果。因此,NSPCs-ES的未来研究和应用可能为未来中枢神经系统疾病的治疗提供新的策略。在这次审查中,我们总结了这些方面的当前进展。
