Abstract：
Candida albicans stands as the foremost prevalent human commensal pathogen and a significant contributor to nosocomial fungal infections. In the metabolism of C. albicans, alcohol dehydrogenase 1 (Adh1) is one of the important enzymes that converts acetaldehyde produced by pyruvate decarboxylation into ethanol at the end of glycolysis. Leveraging the foundational processes of alcoholic fermentation, Adh1 plays an active role in multiple biological phenomena, including biofilm formation, interactions between different species, the development of drug resistance, and the potential initiation of gastrointestinal cancer. Additionally, Adh1 within C. albicans has demonstrated associations with regulating the cell cycle, stress responses, and various intracellular states. Furthermore, Adh1 is extracellularly localized on the cell wall surface, where it plays roles in processes such as tissue invasion and host immune responses. Drawing from an analysis of ADH1 gene structure, expression patterns, and fundamental functions, this review elucidates the intricate connections between Adh1 and various biological processes within C. albicans, underscoring its potential implications for the prevention, diagnosis, and treatment of candidiasis.
摘要：
白色念珠菌是最常见的人类共生病原体，也是医院真菌感染的重要原因。在白色念珠菌的代谢中,乙醇脱氢酶1（Adh1）是在糖酵解结束时将丙酮酸脱羧产生的乙醛转化为乙醇的重要酶之一。利用酒精发酵的基本过程，Adh1在多种生物现象中起着积极的作用，包括生物膜的形成，不同物种之间的相互作用，耐药性的发展，以及可能引发的胃肠道癌症。此外,白色念珠菌中的Adh1已证明与调节细胞周期有关，应激反应，和各种细胞内状态。此外，Adh1位于细胞外的细胞壁表面，它在组织入侵和宿主免疫反应等过程中发挥作用。通过对ADH1基因结构的分析，表达模式，和基本功能，这篇综述阐明了Adh1与白色念珠菌内各种生物过程之间的复杂联系，强调其对预防的潜在影响，诊断,和念珠菌病的治疗。
