PDF(Pubmed)
Abstract：
Psammoma bodies in cervicovaginal cytology are a rare finding associated with malignant tumours. A 62-year-old woman was referred to our centre for cytology with nuclear atypia and psammomatous bodies suspicious of malignancy. A complete gynaecological examination was performed including colposcopy and ultrasound without significant changes. Hysteroscopy was performed to detect endometrial or endocervical malignancy, endometrial biopsy showed psammoma bodies and atrophic endometrium. Endocervical and cervical biopsies were negative for malignancy. Cervicovaginal cytology and human papillomavirus (HPV) testing were repeated. The result was suggestive of adenocarcinoma and negative for HPV. Laparoscopic hysterectomy with bilateral salpingo-oophorectomy was indicated due to two cervicovaginal cytologies with suspicion of malignancy. Low-grade peritoneal serous carcinoma was diagnosed on the surface of the uterus, ovaries and peritoneum. A second laparoscopy was performed to exclude other pelvic or abdominal lesions, and disease was found in the peritoneum of the pelvis, abdomen and omentum. Adjuvant treatment with six cycles of carboplatin and paclitaxel was indicated. Psammoma bodies in cervicovaginal cytology are a rare clinical situation, and it is mandatory to exclude malignancy.
摘要：
宫颈阴道细胞学中的腺瘤体是与恶性肿瘤相关的罕见发现。一名62岁的妇女被转诊到我们的细胞学中心，患有核异型性和可疑恶性肿瘤的砂膜体。进行了完整的妇科检查，包括阴道镜检查和超声检查，无明显变化。进行宫腔镜检查以检测子宫内膜或宫颈内恶性肿瘤，子宫内膜活检显示子宫内膜和萎缩性子宫内膜。宫颈和宫颈活检均为恶性肿瘤阴性。重复宫颈阴道细胞学和人乳头瘤病毒（HPV）检测。结果提示腺癌，HPV阴性。腹腔镜子宫切除术和双侧附件卵巢切除术是由于两个宫颈阴道细胞学检查，怀疑恶性肿瘤。在子宫表面诊断出低度腹膜浆液性癌，卵巢和腹膜。进行第二次腹腔镜检查以排除其他骨盆或腹部病变，在骨盆的腹膜中发现了疾病，腹部和网膜。需要使用六个周期的卡铂和紫杉醇辅助治疗。宫颈阴道细胞学检查是一种罕见的临床情况，并且必须排除恶性肿瘤。
