PDF(Pubmed)
Abstract：
Type B lactic acidosis secondary to the Warburg effect is a rare metabolic complication associated with hematological malignancies. Type B lactic acidosis occurs without tissue dysoxia due to increased aerobic glycolysis and excess lactic acid formation, commonly known as the Warburg effect. Here, we present a case of Burkitt lymphoma in a 69-year-old female with severe type B lactic acidosis and hypoglycemia that was effectively treated by the prompt initiation of chemotherapy. Type B lactic acidosis has been mostly described with hematological malignancies and rarely with solid malignancies. It is considered one of the oncological emergencies, and initiation of chemotherapy as soon as possible has been beneficial compared to alkali therapy. Lactic acidosis associated with malignancies carries a poor prognosis and high mortality.
摘要：
继发于Warburg效应的B型乳酸性酸中毒是与血液恶性肿瘤相关的罕见代谢并发症。B型乳酸性酸中毒的发生没有由于增加的有氧糖酵解和过量的乳酸形成的组织功能障碍，通常被称为Warburg效应。这里,我们介绍一例69岁女性Burkitt淋巴瘤,伴有严重的B型乳酸性酸中毒和低血糖,通过立即开始化疗得到有效治疗.B型乳酸性酸中毒主要被描述为血液恶性肿瘤，很少被描述为实体恶性肿瘤。它被认为是肿瘤紧急情况之一，与碱疗法相比，尽快开始化疗是有益的。与恶性肿瘤相关的乳酸性酸中毒预后差，死亡率高。
